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[参数在预测青少年特发性脊柱侧凸女孩生长高峰身高速度中的价值:一项关于髂嵴软骨的组织形态学研究]

[The value of parameters in predicting the growth peak height velocity of the adolescent idiopathic scoliosis girls: a histomorphological study on iliac crest cartilage].

作者信息

Qiu Yong, Wang Wei-jun, Xia Cai-wei, Zhu Ze-zhang, Zhu Feng

机构信息

Department of Spine Surgery, Drum Tower Hospital, Nanjing University Medical School, Nanjing 210008, China.

出版信息

Zhonghua Wai Ke Za Zhi. 2007 Nov 15;45(22):1557-60.

Abstract

OBJECTIVE

To evaluate the value of some parameters in predicting of growth peak height velocity (PHV) of the girls with adolescent idiopathic scoliosis (AIS) by histomorphological studying on iliac crest cartilage.

METHODS

Iliac crest cartilages were harvested during posterior surgery from girls with AIS. The samples were then paraffin embedded after stored in formalin solid over 24 hours, sectioned vertical to the calcification at the thickness of 5 microm, and stained with Hematoxylin and Eosin. The histological grading of the proliferating activity of it was observed under the microscope. Parameters included chronologic age, menarche status, wrist skeletal age, digital skeletal age, elbow epiphysis and Risser sign were recorded. The histological grading data were compared with these parameters in terms of their accuracy in the prediction of PHV of the scoliosis.

RESULTS

The specimens of 53 AIS patients with an average age 14.0 years were stained successfully. The proliferating activity of the iliac crest cartilage decreased when the AIS girl was over 13.0 years of chronologic age, 14.0 years of wrist skeletal age, post menarche or Risser sign was no less than grade 3.

CONCLUSIONS

All the parameters evaluated can be used to show the end of PHV. Three parameters, including 11 years old of chronologic age, 12 years of the wrist skeletal age, unfusion of the elbow epiphysis and the thelarche, can be used in predicting the beginning of PHV.

摘要

目的

通过对髂嵴软骨进行组织形态学研究,评估某些参数对青少年特发性脊柱侧凸(AIS)女孩生长高峰高度速度(PHV)的预测价值。

方法

在后路手术中采集AIS女孩的髂嵴软骨。样本在福尔马林固定超过24小时后进行石蜡包埋,垂直于钙化方向切片,厚度为5微米,并用苏木精和伊红染色。在显微镜下观察其增殖活性的组织学分级。记录的参数包括实际年龄、月经初潮状态、腕骨骨骼年龄、指骨骨骼年龄、肘部骨骺和Risser征。将组织学分级数据与这些参数在预测脊柱侧凸PHV方面的准确性进行比较。

结果

成功对53例平均年龄14.0岁的AIS患者的标本进行了染色。当AIS女孩实际年龄超过13.0岁、腕骨骨骼年龄超过14.0岁、月经初潮后或Risser征不低于3级时,髂嵴软骨的增殖活性降低。

结论

所有评估的参数均可用于显示PHV的结束。三个参数,包括实际年龄11岁、腕骨骨骼年龄12岁、肘部骨骺未融合和乳房发育,可以用于预测PHV的开始。

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