Kiykim Ahmet Alper, Genctoy Gultekin, Horoz Mehmet, Sari Sibel, Gok Ebru, Coskun Banu, Yilmaz Nejat, Gurses Iclal
Department of Internal Medicine, Division of Nephrology, Faculty of Medicine, University of Mersin, Mersin, Turkey.
Med Sci Monit. 2009 Aug;15(8):CS132-4.
Although the exact role of the diphenylhydantoin treatment on the immune system is still unclear, prolonged administration of diphenylhydantoin has been suggested to be associated with immune-based disorders and syndromes.
A case of fibrillary glomerulonephritis associated with DPH treatment is reported. This is the first reported case of fibrillary glomerulonephritis associated with this commonly used common anticonvulsive drug.
A more routine surveillance for proteinuria in patients receiving DPH is recommended.
尽管二苯妥英治疗对免疫系统的确切作用仍不清楚，但长期使用二苯妥英已被认为与基于免疫的疾病和综合征有关。
报告了一例与二苯妥英治疗相关的纤维性肾小球肾炎病例。这是首例报道的与这种常用抗惊厥药物相关的纤维性肾小球肾炎病例。
建议对接受二苯妥英治疗的患者进行更常规的蛋白尿监测。
