过敏性疾病中免疫耐受的治疗性调控。
Therapeutic manipulation of immune tolerance in allergic disease.
作者信息
Akdis Mübeccel, Akdis Cezmi A
机构信息
Swiss Institute of Allergy and Asthma Research, University of Zurich, Obere Strasse 22, Davos Platz, Switzerland.
出版信息
Nat Rev Drug Discov. 2009 Aug;8(8):645-60. doi: 10.1038/nrd2653.
Immune tolerance - the adaptation of the immune system to external antigens or allergens - might be therapeutically manipulated to restore normal immunity in conditions such as allergy, asthma and autoimmune diseases. The field of allergen-specific immunotherapy is experiencing exciting and novel developments for the treatment of allergic and autoimmune diseases, and recent insights into the reciprocal regulation and counter-balance between different T-cell subsets is foreseen to facilitate new strategies for immunointervention. This Review highlights current knowledge of immunomodulatory therapies for the manipulation of immune tolerance and highlights recent approaches to improve allergen-specific immunotherapy for the treatment of allergic diseases.
免疫耐受——免疫系统对外源抗原或过敏原的适应性——或许可通过治疗手段进行调控，以在诸如过敏、哮喘和自身免疫性疾病等病症中恢复正常免疫。变应原特异性免疫疗法领域在过敏性和自身免疫性疾病的治疗方面正经历着令人兴奋的全新进展，并且预计近期对不同T细胞亚群之间相互调节和制衡的深入了解将推动免疫干预新策略的发展。本综述着重介绍了用于调控免疫耐受的免疫调节疗法的当前知识，并着重介绍了改善变应原特异性免疫疗法以治疗过敏性疾病的最新方法。
Zotero 插件