微小 RNA 作为乳腺癌诊断、预后和治疗靶点的新角色。
MicroRNAs as New Players for Diagnosis, Prognosis, and Therapeutic Targets in Breast Cancer.
机构信息
Department of Surgery, The University of Hong Kong, Hong Kong.
出版信息
J Oncol. 2009;2009:305420. doi: 10.1155/2009/305420. Epub 2009 Jul 27.
Abstract
MicroRNAs are small nonprotein-coding RNAs that regulate the expressions of a wide variety of genes by sequence-specific base pairing on the 3'UTR of mRNA targets resulting in mRNA degradation or inhibition of translation. Aberrant expressions of miRNAs have been linked to tumor development, metastasis, diagnosis, prognosis, and therapy response in human breast cancer. Some miRNAs have been considered to have potential clinical applications as a tool for breast cancer prognosis and therapy. Here we describe and discuss lines of evidence supporting the important relationship between miRNAs and breast cancer, and its therapeutic strategies.
摘要
微小 RNA 是一类小的非蛋白编码 RNA，通过与 mRNA 靶标 3'UTR 上的特异性碱基配对来调节广泛种类的基因表达，导致 mRNA 降解或翻译抑制。miRNA 的异常表达与人类乳腺癌的肿瘤发生、转移、诊断、预后和治疗反应有关。一些 miRNA 已被认为具有作为乳腺癌预后和治疗工具的潜在临床应用价值。本文描述并讨论了支持 miRNA 与乳腺癌及其治疗策略之间重要关系的证据。
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