肾上腺素预处理对清醒和麻醉大鼠缺血及再灌注后心律失常的影响。
Effects of adrenaline pretreatment on the arrhythmias observed following ischemia and reperfusion in conscious and anesthetized rats.
作者信息
Bozdogan Omer, Ekerbicer Nuran, Suveren Eylem, Bikmaz Sevda P
机构信息
Department of Biology, Faculty of Science and Literature, Abant Izzet Baysal University, Bolu;
出版信息
Exp Clin Cardiol. 2002 Spring;7(1):20-4.
A short episode of ischemia induced by coronary artery occlusion can precondition the myocardium against arrhythmia. The factors that have the potential to protect the myocardium from subsequent ischemia and reperfusion are controversial. In this study, the preconditioning-like effects of adrenaline were investigated in both anesthetized and conscious rats. Adrenaline 0.1 and 0.5 mg/kg or saline was administered 10 min before coronary occlusion in conscious and anesthetized rats. The 0.5 mg/kg dose of adrenaline decreased the total duration of arrhythmia in both models. The incidence of ventricular fibrillation decreased and survival rate increased only in conscious rats administered 0.5 mg/kg adrenaline. As a result, it is suggested that exogenous administration of adrenaline before coronary ligation may precondition and protect the heart against arrhythmia.
冠状动脉闭塞诱发的短暂缺血发作可使心肌对心律失常产生预处理作用。有可能保护心肌免受后续缺血和再灌注影响的因素存在争议。在本研究中，在麻醉和清醒大鼠中研究了肾上腺素的预处理样作用。在清醒和麻醉大鼠冠状动脉闭塞前10分钟给予0.1和0.5mg/kg肾上腺素或生理盐水。0.5mg/kg剂量的肾上腺素在两种模型中均降低了心律失常的总持续时间。仅在给予0.5mg/kg肾上腺素的清醒大鼠中，室颤发生率降低且存活率增加。因此，提示冠状动脉结扎前外源性给予肾上腺素可能对心脏具有预处理作用并保护其免受心律失常的影响。
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