Schuster B
Haemochrom Diagnostica GmbH, Renteilichtung 1, 45134 Essen.
Hamostaseologie. 2009 Aug;29(3):268-73.
Vitamin K-antagonists and heparin belong to the established indirect acting anticoagulants. For many years these drugs were the only possibility for prophylaxis and treatment of venous and arterial thrombosis. The challenges for the routine laboratory related to the treatment with vitamin K-antagonists and heparin can be regarded as solved. However, in recent years a rapid development of new anticoagulants began. Although they are developed with guidelines for use without monitoring, the control of effective levels may be necessary in selected cases. As a consequence new challenges for the routine laboratory have to be solved. This paper presents an overview concerning monitoring methods.
维生素K拮抗剂和肝素属于已确立的间接作用抗凝剂。多年来，这些药物一直是预防和治疗静脉及动脉血栓形成的唯一选择。与维生素K拮抗剂和肝素治疗相关的常规实验室面临的挑战可视为已得到解决。然而，近年来新型抗凝剂开始迅速发展。尽管它们是按照无需监测的使用指南研发的，但在某些特定情况下，控制有效水平可能仍有必要。因此，常规实验室必须解决新的挑战。本文概述了相关监测方法。
