Shevtsov V I, Grebeniuk L A, Popkov A V, Grebeniuk E B
Vestn Ross Akad Med Nauk. 2009(6):37-43.
The aim of the work was to examine mechanical and acoustic properties of the skin and collagen metabolism in patients with congenital and developmental malformation (CDM) of extremities. Acoustic tests were performed in 39 patients with forearm CDM and in 30 with leg CDM aged 4-18 years using an ASA-4 apparatus (Russia and Yugoslavia). Mean radial and ulnar lengthening was 6.4 +/- 1.0 (5.5-8) cm, tibial and fibular lengthening 5.0 +/- 1.2 (3-8) cm, and femoral lengthening 6-12 cm. Longitudinalvelocity of sound 1 and 2 months after distraction was 42.3% and 62.9% respectively higher than the preoperative value (p < 0.05). A similar increase (36.8 and 58.4% respectively) was recorded with the ASA-4 sensor in the transverse position. Acoustic inhomogeneity in the thigh skin also increased during distraction. Maximum free to protein-bound hydroxyproline ratio in blood was measured in the end of distraction (0.58 +/- 0.04) and in the beginning of fixation (0.6 +/- 0.01). Its subsequent decrease reflected structural and metabolic changes related to proliferative and biosynthetic processes in the skin, fibrillogenesis, and altered homogeneity patterns.
这项工作的目的是研究四肢先天性和发育性畸形（CDM）患者的皮肤力学和声学特性以及胶原蛋白代谢。使用ASA - 4仪器（俄罗斯和南斯拉夫）对39例4 - 18岁的前臂CDM患者和30例腿部CDM患者进行了声学测试。桡骨和尺骨平均延长6.4±1.0（5.5 - 8）厘米，胫骨和腓骨延长5.0±1.2（3 - 8）厘米，股骨延长6 - 12厘米。牵引后1个月和2个月的纵向声速分别比术前值高42.3%和62.9%（p < 0.05）。使用横向放置的ASA - 4传感器也记录到了类似的增加（分别为36.8%和58.4%）。牵引过程中大腿皮肤的声学不均匀性也增加。在牵引结束时（0.58±0.04）和固定开始时（0.6±0.01）测量了血液中游离羟脯氨酸与蛋白质结合羟脯氨酸的最大比值。其随后的下降反映了与皮肤中的增殖和生物合成过程、纤维形成以及改变的均匀性模式相关的结构和代谢变化。
