Volkov V P
Probl Tuberk Bolezn Legk. 2009(6):24-7.
Eight hundred and thirty autopsy protocols of died patients with schizophrenia from 1952 to 2007 were studied. Respiratory pathology as a cause of death was noted in 29.8% of cases. There are great changes in the study parameters, which have been particularly evident in the past 2 decades: a reduction in the rate of lobar (croupous) and bronchial pneumonia, an increase in the number of cases of active pulmonary tuberculosis and chronic obstructive pulmonary disease, and lung cancer. The higher incidence of the two latter diseases is associated by the author with the side effects of phenothiazine neuroleptics in the long-term treatment of schizophrenia.
对1952年至2007年间830例死于精神分裂症患者的尸检报告进行了研究。29.8%的病例中发现呼吸系统病变是死亡原因。研究参数有很大变化,在过去20年中尤为明显:大叶性(格鲁布性)肺炎和支气管肺炎发病率降低,活动性肺结核、慢性阻塞性肺疾病及肺癌病例数增加。作者认为后两种疾病发病率较高与长期使用吩噻嗪类抗精神病药物治疗精神分裂症的副作用有关。