Zhang S S, Li Z H, Liu S F
Department of Pharmacology, Neimenggu Medical College, Huhehaote.
Yao Xue Xue Bao. 1990;25(8):637-9.
Matrine (Ma) was extracted from the seed and leaves of Sophora alopecuroides L. Ma showed positive inotropic actions in isolated guinea pig left atrium and rat vas deferens under electric stimulation. The positive inotropic actions were markedly inhibited by verapamil (1 mumol/L). Isolated rat vas deferens under the action of Ma showed rhythmic contraction. High K+ (KCl 40 mmol/L) augmented the frequency of rhythmic contraction induced by Ma; conversely, Ma may also augment the increased tension produced by high K+. These results suggest that, the positive inotropic actions of Ma is relevant to its activation of Ca2+ channels.
苦参碱（Ma）从苦豆子的种子和叶子中提取。在电刺激下，Ma对豚鼠离体左心房和大鼠输精管显示出正性肌力作用。维拉帕米（1 μmol/L）可显著抑制这种正性肌力作用。在Ma作用下，离体大鼠输精管呈现节律性收缩。高钾（KCl 40 mmol/L）增加了Ma诱导的节律性收缩频率；相反，Ma也可能增强高钾产生的张力增加。这些结果表明，Ma的正性肌力作用与其激活Ca2+通道有关。
