Gaffar A, Esposito A, Afflitto J
Colgate-Palmolive Technology Center, Piscataway, NJ 08854.
Am J Dent. 1990 Sep;3 Spec No:S37-42.
The effect of PVM/MA copolymer on hydroxyapatite crystal growth in vitro at 37 degrees C was evaluated. The copolymer provided a 50% inhibition of the growth rate at 35 ppm for 220 minutes. The polymer adsorbed to saliva-coated hydroxyapatite disks and the adsorption was time and concentration dependent. Under exaggerated in vitro conditions, the copolymer did not etch or damage enamel surfaces at pH 5.5 and 7.5. It was highly effective against calculus formation in rats when applied topically yielding a 54% reduction (P less than or equal to 0.01). In beagle dogs, it reduced calculus formation significantly (P = 0.06) over a period of 24 to 28 weeks when applied topically either as a rinse or toothpaste. Collectively, the data indicated that the copolymer was an effective anticalculus agent when applied topically, in the presence of triclosan.
评估了PVM/MA共聚物在37℃下对体外羟基磷灰石晶体生长的影响。该共聚物在35 ppm时220分钟内使生长速率抑制了50%。聚合物吸附到涂有唾液的羟基磷灰石盘上，且吸附具有时间和浓度依赖性。在夸大的体外条件下，该共聚物在pH 5.5和7.5时不会蚀刻或损坏牙釉质表面。局部应用时，它对大鼠牙结石形成具有高效性，使牙结石形成减少了54%（P≤0.01）。在比格犬中，当作为漱口水或牙膏局部应用24至28周时，它能显著减少牙结石形成（P = 0.06）。总体而言，数据表明在存在三氯生的情况下局部应用时，该共聚物是一种有效的抗牙结石剂。
