Hüfner Katharina, Stephan Thomas, Hamilton Derek A, Kalla Roger, Glasauer Stefan, Strupp Michael, Brandt Thomas
Department of Neurology, Ludwig-Maximilians University, Munich, Germany.
Ann N Y Acad Sci. 2009 May;1164:383-5. doi: 10.1111/j.1749-6632.2008.03719.x.
It has been shown in blind patients that the abolition of sensory input can lead to changes in white- and cortical gray-matter volumes. Here the white- and gray-matter changes found with whole brain voxel-based morphometry in 16 patients with complete chronic unilateral vestibular deafferentation (UVD) due to vestibular schwannoma removal several years prior are reported on. Subtle deficits in spatial memory and navigation were previously shown in patients with right UVD. Images of the brains of right-UVD patients were flipped, standard preprocessing steps were performed, and the data were modulated. Patients showed a gray-matter volume reduction in the cerebellum due to schwannoma removal, in the supramarginal gyrus ipsilateral to the lesion, as well as in the postcentral and superior temporal gyrus, areas involved in the vestibular cortical network, and in the motion-sensitive area MT/V5. There was no correlation with behavioral navigational abilities. No gray-matter atrophy was found in the insular cortical vestibular region or the hippocampus, both of which receive bilateral vestibular projections. The thalamus and tegmentum of the mesencephalon showed gray-matter reduction on the opposite side; this was possibly due to reduced auditory input, which is known to cross at this level. In comparison to healthy controls, no regional increases in gray-matter volume were seen. No white-matter changes were detected at the selected threshold.
在盲人患者中已表明，感觉输入的消除可导致白质和皮质灰质体积的变化。本文报道了16例因几年前切除前庭神经鞘瘤而导致完全慢性单侧前庭传入神经阻滞（UVD）的患者，通过基于全脑体素的形态学测量发现的白质和灰质变化。先前在右UVD患者中显示出空间记忆和导航方面的细微缺陷。对右UVD患者的脑部图像进行翻转，执行标准预处理步骤，并对数据进行调制。患者因切除神经鞘瘤，小脑、病变同侧的缘上回以及中央后回和颞上回（前庭皮质网络涉及的区域以及运动敏感区域MT/V5）的灰质体积减少。这与行为导航能力无相关性。在岛叶皮质前庭区域或海马体中未发现灰质萎缩，这两个区域均接受双侧前庭投射。中脑的丘脑和被盖在对侧显示灰质减少；这可能是由于已知在此水平交叉的听觉输入减少所致。与健康对照相比，未观察到灰质体积的区域增加。在选定阈值下未检测到白质变化。
