[The effect of delta-9-tetrahydrocannabinol on the receptor and physicochemical properties of the membranes in the rat brain].

It has been demonstrated that delta-9-THC does not affect the specific binding of 3H-IQNB, 3H-DAGO and 3H-dihydroalprenolol, decreases the level of specific binding 3H-LSD and 3H-spiperone, a 2-3-fold increase in the total and nonspecific binding being observed in this case, and also increases the microviscosity of the rat obtain membranes and disrupts lipid-protein interactions. Increasing the microviscosity of membranes by other method (lipid peroxidation) differently affects the binding of radioactively labeled ligands with the membranes from rat brain.