[实验性心脏硬化中红细胞膜微粘度的年龄相关特征]
[Age-related features of microviscosity of erythrocyte membranes in experimental cardiosclerosis].
作者信息
Rebrova T Iu, Afanas'ev S A, Putrova O D, Popov S V
出版信息
Adv Gerontol. 2012;25(4):644-7.
The age-related changes in the coefficient of microviscosity and polarity in the area of lipid-lipid and protein-lipid contacts of erythrocyte membranes in 4 months old (group I, n = 20) and 12 months old (group II, n = 20) rats by the method of lateral diffusion of the pyrene probe were investigated. Each age group consisted of 10 intact animals and animals after postinfarction cardiac remodeling (PICS). An increase of microviscosity and polarity of the annular and total lipids of erythrocyte membranes in 12-month animals was found. When modeling PICS in 4-month animals is pronounced increase the polarity and microviscosity of erythrocyte membranes in the annular and total lipids. The 12-month animals after PICS demonstrate a decrease of microviscosity in a lipid bilayer, and its increase in the area of annular lipids for consistently high-polarity lipids.
采用芘探针侧向扩散法，研究了4月龄（I组，n = 20）和12月龄（II组，n = 20）大鼠红细胞膜脂质-脂质和蛋白质-脂质接触区域微粘度系数和极性的年龄相关变化。每个年龄组由10只完整动物和梗死后心脏重塑（PICS）后的动物组成。发现12月龄动物红细胞膜环形脂质和总脂质的微粘度和极性增加。在4月龄动物中模拟PICS时，红细胞膜环形脂质和总脂质的极性和微粘度显著增加。PICS后的12月龄动物脂质双分子层的微粘度降低，而对于始终具有高极性的脂质，环形脂质区域的微粘度增加。
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