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[γ-氨基丁酸能药物对大鼠神经源性胃损伤发展的影响]

[The effect of GABA-ergic agents on the development of a neurogenic stomach lesion in rats].

作者信息

Bul'on V V, Zavodskaia I S, Khnychenko L K

出版信息

Biull Eksp Biol Med. 1990 Nov;110(11):504-6.

PMID:1964607
Abstract

Neurogenic gastric lesions in rats were induced by combination of immobilization with 3-h long electrostimulation. After this stress a distinct decrease of noradrenalin and creatine phosphate content and then the activation of lipid peroxidation (LPO) in the stomach tissue was recorded. If the stress treatment was preceded by application of piracetam and fenibute, gastric tissue trophic was protected by way of prevention from a decrease of the content of noradrenalin, creatine phosphate and the activation of LPO.

摘要

通过将固定与3小时长时间的电刺激相结合,在大鼠中诱导神经源性胃损伤。在这种应激后,记录到胃组织中去甲肾上腺素和磷酸肌酸含量明显降低,随后脂质过氧化(LPO)被激活。如果在应激处理之前应用吡拉西坦和非尼布特,则通过防止去甲肾上腺素、磷酸肌酸含量降低和LPO激活来保护胃组织营养。

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