Oosterhuis J W, Castedo S M, de Jong B
Department of Pathology, University of Groningen, Netherlands.
Cancer Surv. 1990;9(2):320-32.
Data from cytogenetics of testicular, ovarian and extragonadal germ cell tumours indicate that the group of germ cell tumours for which Skakkebaek proposed the name gonocytoma (seminoma, dysgerminoma and germinoma) is characterized by the presence of isochromosome 12p. The (dysplastic) gonocytes from which these tumours are derived are prone to polyploidization, especially in the gonads. There is evidence that non-seminomatous germ cell tumours in the testis may evolve through a (subclinical?) gonocytoma stage by loss of chromosomes. Since gonocytomas have already acquired the i(12p) marker, evolution of non-seminomatous germ cell tumours from gonocytomas would explain the presence of i(12p) in non-seminomatous germ cell tumours of the adult testis. A similar evolution may account for the presence of i(12p) in testicular type non-seminomatous germ cell tumours occurring in the ovary and extragonadally.
睾丸、卵巢及性腺外生殖细胞肿瘤的细胞遗传学数据表明，斯卡克贝克提出的性腺细胞瘤（精原细胞瘤、无性细胞瘤和生殖细胞瘤）这一生殖细胞肿瘤组的特征是存在12号染色体短臂等臂染色体。这些肿瘤所源自的（发育异常的）生殖母细胞易于多倍体化，尤其是在性腺中。有证据表明，睾丸中的非精原细胞瘤性生殖细胞肿瘤可能通过染色体丢失，经（亚临床？）性腺细胞瘤阶段演变而来。由于性腺细胞瘤已经获得了i(12p)标记，非精原细胞瘤性生殖细胞肿瘤由性腺细胞瘤演变而来可以解释成年睾丸非精原细胞瘤性生殖细胞肿瘤中i(12p)的存在。类似的演变可能解释了卵巢和性腺外发生的睾丸型非精原细胞瘤性生殖细胞肿瘤中i(12p)的存在。
