Camacho Francisco J, García-Horsman Patricia, Paredes Raúl G
Instituto de Neurobiología, Universidad Nacional Autónoma de México, Querétaro, Qro., Mexico.
Horm Behav. 2009 Oct;56(4):410-5. doi: 10.1016/j.yhbeh.2009.07.007. Epub 2009 Jul 28.
The ability to control or pace the sexual interaction has important physiological and behavioral consequences for the female rat. Paced mating favors reproduction and induces a positive affective state as revealed by conditioned place preference (CPP). In the present experiment we evaluated: 1) If paced mating induces CPP in naturally cycling females; 2) If females developed a positive affective state if they paced the sexual interaction through a 1- or a 3-hole pacing chamber; 3) If females that mate with the same male without pacing the sexual interaction develop CPP. In the first experiment intact females were divided in 4 different groups; 2 paced the sexual interaction until receiving 1 or 3 ejaculations; the other 2 groups mated, without pacing the sexual interaction, until receiving 1 or 3 ejaculations. Only the group that paced the sexual interaction until receiving 3 ejaculations developed a positive affective state. In experiments 2 and 3 hormonally treated ovariectomized females were used. In experiment 2 females were allowed to pace the sexual interaction through a 1- or a 3-hole pacing chamber: A clear positive affective state was induced in both testing conditions. Finally, in experiment 3 females did not develop CPP for non-paced sex despite the fact that they mated with the same male in the conditioning sessions. These results demonstrate that the pattern of vaginocervical stimulation that the females received by engaging in approach and avoidance behaviors to pace the sexual interaction can induce a positive affective state in naturally cycling females. They also confirm the existence of a threshold of vaginocervical stimulation for paced mating to induce CPP in female rats.
对雌性大鼠而言，控制或调节性行为的能力具有重要的生理和行为影响。如条件性位置偏爱（CPP）所示，有节奏的交配有利于繁殖并诱发积极的情感状态。在本实验中，我们评估了：1）有节奏的交配是否会在自然发情的雌性大鼠中诱发CPP；2）如果雌性大鼠通过单孔或三孔调节腔来调节性行为，它们是否会产生积极的情感状态；3）与同一雄性大鼠交配但不调节性行为的雌性大鼠是否会产生CPP。在第一个实验中，将未交配过的雌性大鼠分为4个不同的组；其中2组调节性行为，直至接受1次或3次射精；另外2组在不调节性行为的情况下交配，直至接受1次或3次射精。只有调节性行为直至接受3次射精的那组产生了积极的情感状态。在实验2和3中，使用了经激素处理的去卵巢雌性大鼠。在实验2中，让雌性大鼠通过单孔或三孔调节腔来调节性行为：在两种测试条件下均诱发了明显的积极情感状态。最后，在实验3中，尽管雌性大鼠在条件反射阶段与同一雄性大鼠交配，但它们并未因无调节的性行为而产生CPP。这些结果表明，雌性大鼠通过接近和回避行为来调节性行为时所接受的阴道宫颈刺激模式，可在自然发情的雌性大鼠中诱发积极的情感状态。它们还证实了在雌性大鼠中有节奏的交配诱发CPP存在阴道宫颈刺激阈值。
