Department of Pharmaceutical Chemistry, College of Pharmacy, Sri Ramakrishna Institute of Paramedical Sciences, Coimbatore 641044, Tamilnadu, India.
Eur J Med Chem. 2009 Nov;44(11):4690-4. doi: 10.1016/j.ejmech.2009.07.004. Epub 2009 Jul 16.
A series of novel 1-(4-methylcoumarinyl-7-oxyacetyl)-3,5-dimethyl-4(arylazo)pyrazoles and 1-(4-methylcoumarinyl-7-oxyacetyl)-3-methyl-4-(substituted phenyl) hydrazono-2-pyrazolin-5-ones were synthesised and evaluated for antibacterial and antioxidant activities. Compounds 3b, 3g, 5b, 5d and 5g showed good antibacterial activity and compound 5e was found to be the most active antioxidant in the series, and thus represent a new class of promising lead compounds.
一系列新型 1-(4-甲基香豆素基-7-氧乙酰基)-3,5-二甲基-4(芳基偶氮)吡唑啉和 1-(4-甲基香豆素基-7-氧乙酰基)-3-甲基-4-(取代苯基)腙-2-吡唑啉-5-酮被合成并评估了它们的抗菌和抗氧化活性。化合物 3b、3g、5b、5d 和 5g 表现出良好的抗菌活性,而化合物 5e 则是该系列中最具活性的抗氧化剂,因此代表了一类有前途的新型先导化合物。