Slack J M
Department of Zoology, University of Oxford, UK.
J Cell Sci Suppl. 1990;13:119-30. doi: 10.1242/jcs.1990.supplement_13.11.
Factors from two growth factor families have been identified as having mesoderm inducing activity. These include activin and TGF beta 2 from the TGF beta superfamily, and all members of the fibroblast growth factor (FGF) family. When isolated ectoderm explants are treated with any of these factors, a proportion of their cells are caused to differentiate into mesodermal tissue types instead of epidermis. There are several differences in the biological activities which can be broadly summarized by saying that activin yields dorsal type inductions and FGF ventral type inductions. Both bFGF and an FGF receptor have been detected in Xenopus blastulae, but it has not been shown that bFGF is normally secreted from vegetal cells. Various TGF beta-like mRNAs have also been detected and it is expected that an activin-like molecule will prove to be responsible for induction of the dorsal mesoderm in vivo.
已确定来自两个生长因子家族的因子具有中胚层诱导活性。这些因子包括来自转化生长因子β（TGF-β）超家族的激活素和TGF-β2，以及成纤维细胞生长因子（FGF）家族的所有成员。当分离的外胚层外植体用这些因子中的任何一种处理时，它们的一部分细胞会分化为中胚层组织类型而非表皮。这些因子的生物活性存在若干差异，大致可概括为激活素产生背侧型诱导，而FGF产生腹侧型诱导。在非洲爪蟾囊胚中已检测到碱性成纤维细胞生长因子（bFGF）和一种FGF受体，但尚未证明bFGF通常由植物极细胞分泌。也已检测到各种TGF-β样mRNA，预计一种激活素样分子将被证明在体内负责背侧中胚层的诱导。
