Smith J C, Cunliffe V, Green J B, New H V
Laboratory of Developmental Biology, National Institute for Medical Research, Mill Hill, London, U.K.
Philos Trans R Soc Lond B Biol Sci. 1993 Jun 29;340(1293):287-96. doi: 10.1098/rstb.1993.0070.
The mesoderm of amphibian embryos arises through an inductive interaction in which a signal from the vegetal hemisphere of the blastula-stage embryo acts on overlying equatorial cells. Strong candidates for endogenous mesoderm-inducing signals include members of the fibroblast growth factor (FGF) and activin families. In this paper we show that cells form different mesodermal cell types in response to different concentrations of these factors, and that graded distributions of activin and FGF can, in principle, provide sufficient positional information to generate the body plan of the Xenopus embryo.
两栖动物胚胎的中胚层通过一种诱导相互作用产生，其中囊胚期胚胎植物半球发出的信号作用于覆盖其上的赤道细胞。内源性中胚层诱导信号的有力候选者包括成纤维细胞生长因子（FGF）家族和激活素家族的成员。在本文中，我们表明细胞会根据这些因子的不同浓度形成不同的中胚层细胞类型，并且激活素和FGF的梯度分布原则上可以提供足够的位置信息来生成非洲爪蟾胚胎的身体结构。
