Chen Yuewen, Cao Lingzhi, Ye Jianwei, Zhu Dahai
Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Tsinghua University, Dong Dan San Tiao, Beijing, China.
Biochem Biophys Res Commun. 2009 Oct 9;388(1):112-6. doi: 10.1016/j.bbrc.2009.07.129. Epub 2009 Jul 30.
Myostatin is a strong inhibitor of muscle growth, and its expression is increased in several types of muscle atrophy. However, whether or not myostatin expression is altered in muscle atrophy associated with type 1 diabetes (T1D) remains uncertain. In this study, we provided experimental evidence to show that myostatin mRNA increased in the early stage of T1D but came back to control levels later on. This expression pattern was closely correlated with the loss of body weight and atrogin-1 expression. Furthermore, induction of myostatin expression could be attenuated by insulin in T1D mice. Taken together, our findings indicate that the upregulation of myostatin expression most likely contributes to the muscle atrophy process during insulin deficiency.
肌肉生长抑制素是肌肉生长的强效抑制剂，其表达在几种类型的肌肉萎缩中会增加。然而，在1型糖尿病（T1D）相关的肌肉萎缩中，肌肉生长抑制素的表达是否改变仍不确定。在本研究中，我们提供了实验证据表明，肌肉生长抑制素mRNA在T1D早期增加，但随后恢复到对照水平。这种表达模式与体重减轻和萎缩基因1（atrogin-1）的表达密切相关。此外，在T1D小鼠中，胰岛素可减弱肌肉生长抑制素表达的诱导。综上所述，我们的研究结果表明，在胰岛素缺乏期间，肌肉生长抑制素表达的上调很可能促成了肌肉萎缩过程。
