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MOTS-c: Magical Molecule for Diabetic Cardiomyopathy?

作者信息

Yerra Veera Ganesh, Connelly Kim A

机构信息

Keenan Research Center for Biomedical Science, Li Ka Shing Knowledge Institute, St. Michael's Hospital, 30 bond St, Toronto, ON, M5B1W8, Canada.

Department of Physiology, University of Toronto, Toronto, ON, Canada.

出版信息

Cardiovasc Drugs Ther. 2025 Jun;39(3):473-476. doi: 10.1007/s10557-025-07689-y. Epub 2025 Apr 2.

DOI:10.1007/s10557-025-07689-y
PMID:40172798
Abstract
摘要

相似文献

1
MOTS-c: Magical Molecule for Diabetic Cardiomyopathy?MOTS-c：糖尿病心肌病的神奇分子？
Cardiovasc Drugs Ther. 2025 Jun;39(3):473-476. doi: 10.1007/s10557-025-07689-y. Epub 2025 Apr 2.
2
MOTS-c Peptide Attenuated Diabetic Cardiomyopathy in STZ-Induced Type 1 Diabetic Mouse Model.MOTS-c肽减轻链脲佐菌素诱导的1型糖尿病小鼠模型中的糖尿病性心肌病。
Cardiovasc Drugs Ther. 2023 Dec 23. doi: 10.1007/s10557-023-07540-2.
3
MOTS-c repairs myocardial damage by inhibiting the CCN1/ERK1/2/EGR1 pathway in diabetic rats.MOTS-c通过抑制糖尿病大鼠体内的CCN1/ERK1/2/EGR1信号通路来修复心肌损伤。
Front Nutr. 2023 Jan 4;9:1060684. doi: 10.3389/fnut.2022.1060684. eCollection 2022.
4
The protective effect of the mitochondrial-derived peptide MOTS-c on LPS-induced septic cardiomyopathy.线粒体衍生肽 MOTS-c 对脂多糖诱导的脓毒症性心肌病的保护作用。
Acta Biochim Biophys Sin (Shanghai). 2023 Feb 25;55(2):285-294. doi: 10.3724/abbs.2023006.
5
MOTS-c regulates the ROS/TXNIP/NLRP3 pathway to alleviate diabetic cardiomyopathy.心肌代谢物-c通过调节ROS/TXNIP/NLRP3信号通路减轻糖尿病心肌病。
Biochem Biophys Res Commun. 2024 Dec 31;741:151072. doi: 10.1016/j.bbrc.2024.151072. Epub 2024 Nov 28.
6
An 8-Week study on the effects of high and Moderate-Intensity interval exercises on mitochondrial MOTS-C changes and their relation to metabolic markers in male diabetic sand rats.一项为期 8 周的研究，旨在探讨高和中等强度间歇运动对雄性糖尿病沙鼠线粒体 MOTS-C 变化及其与代谢标志物关系的影响。
Diabetes Res Clin Pract. 2024 Jun;212:111656. doi: 10.1016/j.diabres.2024.111656. Epub 2024 Apr 16.
7
Could MOTS-c Levels in Children with Type 1 Diabetes Mellitus Be an Indicator for Early Diabetic Kidney Disease?1型糖尿病患儿的线粒体衍生肽-c水平能否作为早期糖尿病肾病的指标？
J Clin Res Pediatr Endocrinol. 2025 May 27;17(2):168-175. doi: 10.4274/jcrpe.galenos.2024.2024-5-6. Epub 2024 Dec 23.
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The role of MOTS-c-mediated antioxidant defense in aerobic exercise alleviating diabetic myocardial injury.MOTS-c 介导的抗氧化防御在有氧运动缓解糖尿病心肌损伤中的作用。
Sci Rep. 2023 Nov 13;13(1):19781. doi: 10.1038/s41598-023-47073-0.
9
MOTS-c and Exercise Restore Cardiac Function by Activating of NRG1-ErbB Signaling in Diabetic Rats.MOTS-c 通过激活糖尿病大鼠 NRG1-ErbB 信号恢复心脏功能。
Front Endocrinol (Lausanne). 2022 Mar 17;13:812032. doi: 10.3389/fendo.2022.812032. eCollection 2022.
10
MOTS-c mimics exercise to combat diabetic liver fibrosis by targeting Keap1-Nrf2-Smad2/3.运动诱导的微小RNA-细胞外囊泡通过靶向Keap1-Nrf2-Smad2/3模拟运动来对抗糖尿病性肝纤维化。
Sci Rep. 2025 May 27;15(1):18460. doi: 10.1038/s41598-025-03526-2.

本文引用的文献

1
MOTS-c regulates the ROS/TXNIP/NLRP3 pathway to alleviate diabetic cardiomyopathy.心肌代谢物-c通过调节ROS/TXNIP/NLRP3信号通路减轻糖尿病心肌病。
Biochem Biophys Res Commun. 2024 Dec 31;741:151072. doi: 10.1016/j.bbrc.2024.151072. Epub 2024 Nov 28.
2
MOTS-c Peptide Attenuated Diabetic Cardiomyopathy in STZ-Induced Type 1 Diabetic Mouse Model.MOTS-c肽减轻链脲佐菌素诱导的1型糖尿病小鼠模型中的糖尿病性心肌病。
Cardiovasc Drugs Ther. 2023 Dec 23. doi: 10.1007/s10557-023-07540-2.
3
MOTS-c: A promising mitochondrial-derived peptide for therapeutic exploitation.
MOTS-c：一种有前途的治疗性利用的线粒体衍生肽。
Front Endocrinol (Lausanne). 2023 Jan 25;14:1120533. doi: 10.3389/fendo.2023.1120533. eCollection 2023.
4
MOTS-c repairs myocardial damage by inhibiting the CCN1/ERK1/2/EGR1 pathway in diabetic rats.MOTS-c通过抑制糖尿病大鼠体内的CCN1/ERK1/2/EGR1信号通路来修复心肌损伤。
Front Nutr. 2023 Jan 4;9:1060684. doi: 10.3389/fnut.2022.1060684. eCollection 2022.
5
Mitochondria-derived peptide MOTS-c: effects and mechanisms related to stress, metabolism and aging.线粒体衍生肽 MOTS-c：与应激、代谢和衰老相关的作用和机制。
J Transl Med. 2023 Jan 20;21(1):36. doi: 10.1186/s12967-023-03885-2.
6
The mitochondrial signaling peptide MOTS-c improves myocardial performance during exercise training in rats.线粒体信号肽 MOTS-c 可改善大鼠运动训练中心肌功能。
Sci Rep. 2021 Oct 11;11(1):20077. doi: 10.1038/s41598-021-99568-3.
7
AICAr, a Widely Used AMPK Activator with Important AMPK-Independent Effects: A Systematic Review.AICAr，一种广泛使用的 AMPK 激活剂，具有重要的 AMPK 非依赖性作用：系统评价。
Cells. 2021 May 4;10(5):1095. doi: 10.3390/cells10051095.
8
MOTS-c reduces myostatin and muscle atrophy signaling.运动诱发的循环微小肽-c减少肌肉生长抑制素和肌肉萎缩信号。
Am J Physiol Endocrinol Metab. 2021 Apr 1;320(4):E680-E690. doi: 10.1152/ajpendo.00275.2020. Epub 2021 Feb 8.
9
MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis.MOTS-c 是一种运动诱导的线粒体编码调节因子，可调节与年龄相关的身体衰退和肌肉内稳态。
Nat Commun. 2021 Jan 20;12(1):470. doi: 10.1038/s41467-020-20790-0.
10
MOTS-c peptide increases survival and decreases bacterial load in mice infected with MRSA.运动诱导的C肽（MOTS-c）可提高感染耐甲氧西林金黄色葡萄球菌（MRSA）小鼠的存活率并降低其细菌载量。
Mol Immunol. 2017 Dec;92:151-160. doi: 10.1016/j.molimm.2017.10.017. Epub 2017 Nov 1.