在一个撒丁岛样本中，锂盐完全应答者与DRD1、DRD2、DRD3、DAT1、5-HTTLPR和HTR2A基因之间无关联。
No association between lithium full responders and the DRD1, DRD2, DRD3, DAT1, 5-HTTLPR and HTR2A genes in a Sardinian sample.
作者信息
Manchia Mirko, Congiu Donatella, Squassina Alessio, Lampus Simona, Ardau Raffaella, Chillotti Caterina, Severino Giovanni, Del Zompo Maria
机构信息
Section of Clinical Pharmacology, Department of Neurosciences "B.B. Brodie", University of Cagliari, P.O. San Giovanni di Dio, Via Ospedale 46, 09124 Cagliari, Italy.
出版信息
Psychiatry Res. 2009 Sep 30;169(2):164-6. doi: 10.1016/j.psychres.2008.12.004. Epub 2009 Jul 31.
Polymorphisms within the DRD1, DRD2, DRD3, DAT1, 5-HTTLPR and HTR2A genes are being studied for association with lithium prophylaxis in a sample of 155 Sardinian unrelated probands affected by bipolar disorder (BP). No significant association was shown between the polymorphisms of the genes studied and response to lithium treatment.
在一个由155名患有双相情感障碍（BP）的撒丁岛无血缘关系先证者组成的样本中，正在研究DRD1、DRD2、DRD3、DAT1、5-HTTLPR和HTR2A基因内的多态性与锂盐预防治疗的关联性。所研究基因的多态性与锂盐治疗反应之间未显示出显著关联。
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