Kang Seung-Gul, Lee Heon-Jeong, Choi Jung-Eun, Park Young-Min, Park Jeong-Hyun, Han Changsu, Kim Yong-Ku, Kim Seung-Hyun, Lee Min-Soo, Joe Sook-Haeng, Jung In-Kwa, Kim Leen
Department of Psychiatry, Korea University College of Medicine, Seoul, South Korea.
Neuropsychobiology. 2008;57(1-2):49-54. doi: 10.1159/000129667. Epub 2008 May 2.
The cause of restless legs syndrome (RLS) is not yet clear, but more promising theories involve dopaminergic deficiency and genetic causes. This study investigated whether single-nucleotide polymorphisms in the genes of dopamine receptors DRD1, DRD2, DRD3 and DRD4 are associated with antipsychotics-induced RLS in schizophrenia.
We evaluated 190 Korean schizophrenic patients using the diagnostic criteria of the International Restless Legs Syndrome Study Group and its rating scale for RLS. Genotyping was performed for the DRD1 gene -48A/G, DRD2 gene TaqI A, DRD3 gene Ser9Gly and DRD4 gene -521C/T single-nucleotide polymorphisms. The method of multifactor dimensionality reduction was used to analyze gene-gene interactions.
We classified the schizophrenic patients into 96 with and 94 without RLS symptoms. The genotype frequencies of all polymorphisms investigated did not differ significantly between these 2 groups. MDR analysis did not show a significant effect of the 4 dopamine receptor gene variants on susceptibility to antipsychotic-induced RLS symptoms (p > 0.05).
These genetics data suggest that the analyzed polymorphisms of the dopamine genes may not be associated with RLS symptoms in schizophrenia. Confirming the results reported here requires a larger-scale study involving patients taking specific antipsychotics.
不安腿综合征（RLS）的病因尚不清楚，但更有前景的理论涉及多巴胺能缺乏和遗传因素。本研究调查了多巴胺受体DRD1、DRD2、DRD3和DRD4基因中的单核苷酸多态性是否与精神分裂症患者中抗精神病药物所致的RLS相关。
我们使用国际不安腿综合征研究组的诊断标准及其RLS评定量表对190名韩国精神分裂症患者进行了评估。对DRD1基因-48A/G、DRD2基因TaqI A、DRD3基因Ser9Gly和DRD4基因-521C/T单核苷酸多态性进行基因分型。采用多因素降维法分析基因-基因相互作用。
我们将精神分裂症患者分为96例有RLS症状和94例无RLS症状两组。这两组之间所有研究的多态性的基因型频率没有显著差异。多因素降维分析未显示4种多巴胺受体基因变异对抗精神病药物所致RLS症状易感性有显著影响（p>0.05）。
这些遗传学数据表明，所分析的多巴胺基因多态性可能与精神分裂症患者的RLS症状无关。要证实此处报告的结果，需要开展一项涉及服用特定抗精神病药物患者的更大规模研究。
