Cresson D H, Goldsmith M, Askin F B, Reddick R L, Postma D S, Siegal G P
University of North Carolina, School of Medicine, Chapel Hill.
Pathol Res Pract. 1990 Dec;186(6):795-800; discussion 801-2. doi: 10.1016/S0344-0338(11)80273-6.
The biological behavior of pleomorphic adenomas (mixed tumors) of salivary gland origin is complex. Tumors with benign histologic features may exhibit recurrence and locally aggressive behavior especially after incomplete excision. A small percentage of pleomorphic adenomas have obvious malignant components in epithelial or in both epithelial and mesenchymal components and can metastasize. There are also rare case reports which appear to document typical pleomorphic adenomas of salivary gland with histologically identical visceral and lymph node metastases. Recently myoepithelial cell proliferation has been identified as a possible predictor of aggressive clinical behavior in otherwise histologically benign pleomorphic adenomas. We report such a parotid gland lesion with local recurrence and retroperitoneal spread. DNA-flow cytometry of cells from the paraffin-embedded primary and metastasis showed similar aneuploid populations. Aneuploidy appeared to reflect the malignant potential of this particular pleomorphic adenoma and suggests that DNA-flow cytometry of salivary gland tumors may yield important prognostic information.
涎腺来源的多形性腺瘤（混合瘤）的生物学行为复杂。具有良性组织学特征的肿瘤可能会复发并表现出局部侵袭性行为，尤其是在切除不完全之后。一小部分多形性腺瘤在上皮成分或上皮和间充质成分中具有明显的恶性成分，并可发生转移。也有罕见的病例报告似乎记录了具有组织学上相同的内脏和淋巴结转移的典型涎腺多形性腺瘤。最近，肌上皮细胞增殖已被确定为在组织学上为良性的多形性腺瘤中侵袭性临床行为的一个可能预测指标。我们报告了这样一例伴有局部复发和腹膜后扩散的腮腺病变。来自石蜡包埋的原发肿瘤和转移灶的细胞的DNA流式细胞术显示出相似的非整倍体群体。非整倍体似乎反映了这种特定多形性腺瘤的恶性潜能，并表明涎腺肿瘤的DNA流式细胞术可能产生重要的预后信息。
