Rao Ashwini K, Louis Elan D, Marder Karen S
Department of Rehabilitation Medicine, Columbia University Medical Center, New York, NY 10032, USA.
Gait Posture. 2009 Oct;30(3):391-3. doi: 10.1016/j.gaitpost.2009.07.006. Epub 2009 Jul 31.
Quantitative movement analysis can detect impairments in mobility and balance in persons with pre-symptomatic HD (pre-HD); however, it is not known whether clinical tests can also detect such impairments. Given the ease of administering clinical tests, and the importance of assessing mobility and balance, we examined whether clinical tests can detect motor impairments in individuals with pre-symptomatic HD.
Two clinical tests (Functional Reach Test [FRT] and Timed Up and Go [TUG]) and the Unified Huntington's Disease Rating Scale (UHDRS) were administered, along with quantitative gait analysis, to 15 individuals with pre-symptomatic HD and 15 controls.
There was no difference in FRT and TUG scores across groups. Neither test was correlated with years to predicted disease onset or with quantitative gait analysis measures.
Clinical assessments such as FRT and TUG are not sensitive in detecting motor impairments in individuals with pre-symptomatic HD. The subtle nature of impairments provides a rationale for the use of quantitative gait analysis in pre-symptomatic HD.
定量运动分析能够检测出症状前亨廷顿舞蹈病（pre-HD）患者的运动和平衡障碍；然而，尚不清楚临床测试是否也能检测出此类障碍。鉴于临床测试易于实施，且评估运动和平衡十分重要，我们研究了临床测试能否检测出症状前HD个体的运动障碍。
对15例症状前HD个体和15名对照者进行了两项临床测试（功能性伸展测试 [FRT] 和定时起立行走测试 [TUG]）以及统一亨廷顿舞蹈病评定量表（UHDRS），同时进行了定量步态分析。
各组间FRT和TUG评分无差异。两项测试均与预测疾病发作年限或定量步态分析指标无关。
FRT和TUG等临床评估对检测症状前HD个体的运动障碍不敏感。障碍的细微性质为在症状前HD中使用定量步态分析提供了理论依据。
