亨廷顿舞蹈病运动和平衡障碍的临床测量：效度与反应性
Clinical measurement of mobility and balance impairments in Huntington's disease: validity and responsiveness.
作者信息
Rao Ashwini K, Muratori Lisa, Louis Elan D, Moskowitz Carol B, Marder Karen S
机构信息
Department of Rehabilitation Medicine, Columbia University Medical Center, United States.
出版信息
Gait Posture. 2009 Apr;29(3):433-6. doi: 10.1016/j.gaitpost.2008.11.002. Epub 2008 Dec 25.
BACKGROUND
Mobility and balance in Huntington's disease (HD) are currently assessed in the clinic with three items from the unified Huntington's disease rating scale (UHDRS): walk, tandem and pull tests. These tests may not be optimal because they are scored on an ordinal scale and do not test anticipatory balance. We tested the validity and responsiveness of three clinical tests of mobility and balance.
METHODS
Three clinical tests (FRT, timed up and go (TUG), Berg balance scale (BBS)) were validated with seven quantitative gait measures and two indicators of functional limitation (HD-ADL and total functional capacity) in 30 subjects with HD. These tests were also assessed for responsiveness to disease severity.
RESULTS
FRT and BBS were correlated with five quantitative gait measures, and TUG with eight (all p<0.05). All tests were correlated with indicators of functional limitation (p<0.05) and were responsive to disease severity.
CONCLUSIONS
FRT, TUG and BBS are valid, responsive and easy to administer clinical tests that should be routinely included with the UHDRS in therapeutic trials for subjects with HD.
背景
目前在临床上，亨廷顿舞蹈病（HD）的运动能力和平衡能力是通过统一亨廷顿舞蹈病评定量表（UHDRS）中的三个项目来评估的：步行、前后脚站立和拉测试。这些测试可能并非最佳选择，因为它们是按顺序评分的，且未测试预期平衡能力。我们对三项运动能力和平衡能力的临床测试的有效性和反应性进行了测试。
方法
在30名HD患者中，使用七项定量步态测量指标以及两项功能受限指标（HD-ADL和总功能能力）对三项临床测试（FRT、定时起立行走测试（TUG）、伯格平衡量表（BBS））进行了验证。还评估了这些测试对疾病严重程度的反应性。
结果
FRT和BBS与五项定量步态测量指标相关，TUG与八项相关（所有p<0.05）。所有测试均与功能受限指标相关（p<0.05），且对疾病严重程度有反应。
结论
FRT、TUG和BBS是有效、有反应性且易于实施的临床测试，在针对HD患者的治疗试验中应常规将其与UHDRS一起使用。
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