Mazzarella Claudia, Terracciano Daniela, Di Carlo Angelina, Macchia Paolo Emidio, Consiglio Eduardo, Macchia Vincenzo, Mariano Angela
Dipartimento di Biologia e Patologia Cellulare e Molecolare L Califano, Università degli Studi di Napoli Federico II, Naples, Italy.
Nutrition. 2009 Sep;25(9):926-9. doi: 10.1016/j.nut.2009.01.020.
Mild iodine deficiency was first documented in Campania in the 1990s. We assessed the urinary iodine nutritional status of schoolchildren in Campania before the introduction of legislation for salt iodization and compared the findings with previous results to evaluate to what extent "silent" iodine prophylaxis, which accompanies socioeconomic advances, affects iodine status.
We examined 10552 schoolchildren aged 9-13 y from the five Campania provinces. The study was conducted from April 1999 to October 2002. Urinary iodine excretion was measured in morning urine samples with the AutoAnalyzer 3, an automated system based on the Sandell-Kolthoff reaction. Data were interpreted according to World Health Organization criteria.
The median urinary iodine excretion level in Campania was less than 100 micromicrog/L, which indicates insufficient iodine intake. Mild iodine deficiency was identified in all provinces, namely Napoli, Salerno, Caserta, Avellino, and Benevento, with median urinary iodine excretions of 87, 81, 72, 64, and 61 microg/L, respectively. Overall, the analysis of frequency distribution showed values below 50 and 100 microg/L in 32% and 61% of children, respectively. These values were lower than those previously reported for Campania.
This study confirms that Campania is a mild iodine deficiency area. The decrease in iodine deficiency versus previous studies indicates that silent prophylaxis plays a relevant role in this condition, but it is not sufficient to eradicate it. Our data will serve as a basis for future evaluations of iodine status in Campania.
20世纪90年代，坎帕尼亚首次记录到轻度碘缺乏情况。我们评估了在实施食盐碘化立法之前坎帕尼亚学童的尿碘营养状况，并将结果与之前的进行比较，以评估伴随社会经济进步的“隐性”碘预防措施在多大程度上影响碘状况。
我们检查了来自坎帕尼亚五个省份的10552名9至13岁的学童。该研究于1999年4月至2002年10月进行。使用基于桑德尔 - 科尔托夫反应的自动分析仪3对晨尿样本中的尿碘排泄量进行测量。数据根据世界卫生组织标准进行解读。
坎帕尼亚的尿碘排泄中位数水平低于100微克/升，这表明碘摄入不足。在所有省份，即那不勒斯、萨勒诺、卡塞塔、阿韦利诺和贝内文托，均发现了轻度碘缺乏，尿碘排泄中位数分别为87、81、72、64和61微克/升。总体而言，频率分布分析显示，分别有32%和61%的儿童尿碘值低于50和100微克/升。这些值低于之前报道的坎帕尼亚的数值。
本研究证实坎帕尼亚是轻度碘缺乏地区。与之前的研究相比，碘缺乏情况有所减轻，这表明隐性预防在这种情况下发挥了重要作用，但还不足以根除碘缺乏。我们的数据将作为未来评估坎帕尼亚碘状况的基础。
