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1
[Diabetic nephropathy and cardiovascular risk].[糖尿病肾病与心血管风险]
Aten Primaria. 2010 Mar;42(3):173-5. doi: 10.1016/j.aprim.2009.06.004. Epub 2009 Aug 3.
2
Microalbuminuria: a common, independent cardiovascular risk factor, especially but not exclusively in type 2 diabetes.微量白蛋白尿：一种常见的独立心血管危险因素，尤其但不限于在2型糖尿病中。
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[Is microalbuminuria, an early marker of clinical nephropathy, also a cardiovascular risk factor?].[微量白蛋白尿作为临床肾病的早期标志物，它也是心血管危险因素吗？]
Ann Biol Clin (Paris). 1998 Nov-Dec;56(6):671-9.
4
Elevated levels of plasma von Willebrand factor and the risk of macro- and microvascular disease in type 2 diabetic patients with microalbuminuria.2型糖尿病合并微量白蛋白尿患者血浆血管性血友病因子水平升高与大血管和微血管疾病风险
Nephrol Dial Transplant. 2001 Oct;16(10):2028-33. doi: 10.1093/ndt/16.10.2028.
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[Microalbuminuria. From diabetes to cardiovascular risk].[微量白蛋白尿。从糖尿病到心血管风险]
Vnitr Lek. 2011 Mar;57(3):293-8.
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The risk of cardiovascular disease mortality associated with microalbuminuria and gross proteinuria in persons with older-onset diabetes mellitus.老年糖尿病患者中微量白蛋白尿和大量蛋白尿与心血管疾病死亡率的相关性
Arch Intern Med. 2000 Apr 24;160(8):1093-100. doi: 10.1001/archinte.160.8.1093.
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Microalbuminuria as a marker of cardiovascular and renal risk in type 2 diabetes mellitus: a temporal perspective.微量白蛋白尿作为2型糖尿病心血管和肾脏风险的标志物：时间角度的探讨
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Microalbuminuria: a marker to increased renal and cardiovascular risk in diabetes mellitus.微量白蛋白尿：糖尿病患者肾脏和心血管疾病风险增加的一个标志物。
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9
[Microalbuminuria and diabetic nephropathy. Detection and correlation with other degenerative complications].[微量白蛋白尿与糖尿病肾病。检测及其与其他退行性并发症的相关性]
Presse Med. 1990 Jun 9;19(23):1075-80.
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[Diabetic nephropathy].[糖尿病肾病]
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Effectiveness comparisons of acupuncture for diabetic nephropathy proteinuria: A systematic review and meta-analysis: study protocol.针刺治疗糖尿病肾病蛋白尿的疗效比较：一项系统评价与Meta分析：研究方案
Medicine (Baltimore). 2019 Nov;98(47):e17819. doi: 10.1097/MD.0000000000017819.
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Effectiveness comparisons of traditional Chinese medicine on treating diabetic nephropathy proteinuria: A systematic review and meta-analysis.中药治疗糖尿病肾病蛋白尿的疗效比较：一项系统评价与Meta分析
Medicine (Baltimore). 2019 Oct;98(43):e17495. doi: 10.1097/MD.0000000000017495.
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A Meta-Analysis of the Clinical Efficacy of TCM Decoctions Made from Formulas in the Liuwei Dihuang Wan Categorized Formulas in Treating Diabetic Nephropathy Proteinuria.六味地黄丸类方中药复方治疗糖尿病肾病蛋白尿临床疗效的Meta分析
Evid Based Complement Alternat Med. 2018 Sep 26;2018:2427301. doi: 10.1155/2018/2427301. eCollection 2018.

本文引用的文献

1
10-year follow-up of intensive glucose control in type 2 diabetes.2型糖尿病强化血糖控制的10年随访
N Engl J Med. 2008 Oct 9;359(15):1577-89. doi: 10.1056/NEJMoa0806470. Epub 2008 Sep 10.
2
Albuminuria and risk of cardiovascular events, death, and heart failure in diabetic and nondiabetic individuals.糖尿病和非糖尿病个体中的蛋白尿与心血管事件、死亡及心力衰竭风险
JAMA. 2001 Jul 25;286(4):421-6. doi: 10.1001/jama.286.4.421.
3
Excess mortality in a population with diabetes and the impact of material deprivation: longitudinal, population based study.糖尿病患者群体中的超额死亡率及物质匮乏的影响：基于人群的纵向研究
BMJ. 2001 Jun 9;322(7299):1389-93. doi: 10.1136/bmj.322.7299.1389.
4
Effect of intensive glycemic control on microalbuminuria in type 2 diabetes. Veterans Affairs Cooperative Study on Glycemic Control and Complications in Type 2 Diabetes Feasibility Trial Investigators.强化血糖控制对2型糖尿病患者微量白蛋白尿的影响。退伍军人事务部2型糖尿病血糖控制与并发症合作研究可行性试验研究人员。
Diabetes Care. 2000 Oct;23(10):1478-85. doi: 10.2337/diacare.23.10.1478.
5
The risk of cardiovascular disease mortality associated with microalbuminuria and gross proteinuria in persons with older-onset diabetes mellitus.老年糖尿病患者中微量白蛋白尿和大量蛋白尿与心血管疾病死亡率的相关性
Arch Intern Med. 2000 Apr 24;160(8):1093-100. doi: 10.1001/archinte.160.8.1093.
6
Diabetes and cardiovascular disease: a statement for healthcare professionals from the American Heart Association.糖尿病与心血管疾病：美国心脏协会给医疗保健专业人员的声明
Circulation. 1999 Sep 7;100(10):1134-46. doi: 10.1161/01.cir.100.10.1134.
7
Risk factors for coronary artery disease in non-insulin dependent diabetes mellitus: United Kingdom Prospective Diabetes Study (UKPDS: 23).非胰岛素依赖型糖尿病患者冠状动脉疾病的危险因素：英国前瞻性糖尿病研究（UKPDS：23）
BMJ. 1998 Mar 14;316(7134):823-8. doi: 10.1136/bmj.316.7134.823.
8
Cohort study of predictive value of urinary albumin excretion for atherosclerotic vascular disease in patients with insulin dependent diabetes.胰岛素依赖型糖尿病患者尿白蛋白排泄对动脉粥样硬化性血管疾病预测价值的队列研究。
BMJ. 1996 Apr 6;312(7035):871-4. doi: 10.1136/bmj.312.7035.871.
9
The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus.糖尿病强化治疗对胰岛素依赖型糖尿病长期并发症发生及进展的影响。
N Engl J Med. 1993 Sep 30;329(14):977-86. doi: 10.1056/NEJM199309303291401.
10
Screening and management of microalbuminuria in patients with diabetes mellitus: recommendations to the Scientific Advisory Board of the National Kidney Foundation from an ad hoc committee of the Council on Diabetes Mellitus of the National Kidney Foundation.
Am J Kidney Dis. 1995 Jan;25(1):107-12. doi: 10.1016/0272-6386(95)90636-3.

[糖尿病肾病与心血管风险]

[Diabetic nephropathy and cardiovascular risk].

作者信息

Avila Lachica Luis, Gómez García Ma Carmen

机构信息

Consultorio de Almachar, Centro de Salud Axarquía Oeste, Málaga, España.

出版信息

Aten Primaria. 2010 Mar;42(3):173-5. doi: 10.1016/j.aprim.2009.06.004. Epub 2009 Aug 3.

DOI:10.1016/j.aprim.2009.06.004
PMID:19647899
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7022067/
Abstract

The importance of the early detection of diabetic nephropathy is because it is a cardiovascular risk marker and it indicates the existence of vascular changes associated to an increase risk of having a cardiovascular event in diabetes mellitus type 1 (DM 1), as well as in type 2 (DM 2). Microalbuminuria is a risk factor for overall cardiovascular and coronary mortality in the patients with DM 1. Total mortality is increased in patients with DM 2 and microalbuminuria with a RR of 1.8, and it is related to microalbuminuria levels even below the considered normal range (20 microg/min and/or 30 mg/day). For this reason, the definition of microalbuminuria must be reviewed in the patients with DM 2. More studies are needed to confirm the predictive power of microalbuminuria in cardiovascular and coronary disease.

摘要

早期发现糖尿病肾病很重要，因为它是一种心血管风险标志物，表明在1型糖尿病（DM 1）以及2型糖尿病（DM 2）中存在与心血管事件风险增加相关的血管变化。微量白蛋白尿是DM 1患者总体心血管和冠状动脉死亡的危险因素。DM 2和微量白蛋白尿患者的总死亡率增加，相对危险度为1.8，甚至与低于公认正常范围（20微克/分钟和/或30毫克/天）的微量白蛋白尿水平有关。因此，必须重新审视DM 2患者微量白蛋白尿的定义。需要更多研究来证实微量白蛋白尿在心血管和冠状动脉疾病中的预测能力。