[糖尿病肾病与心血管风险]
[Diabetic nephropathy and cardiovascular risk].
作者信息
Avila Lachica Luis, Gómez García Ma Carmen
机构信息
Consultorio de Almachar, Centro de Salud Axarquía Oeste, Málaga, España.
出版信息
Aten Primaria. 2010 Mar;42(3):173-5. doi: 10.1016/j.aprim.2009.06.004. Epub 2009 Aug 3.
Abstract
The importance of the early detection of diabetic nephropathy is because it is a cardiovascular risk marker and it indicates the existence of vascular changes associated to an increase risk of having a cardiovascular event in diabetes mellitus type 1 (DM 1), as well as in type 2 (DM 2). Microalbuminuria is a risk factor for overall cardiovascular and coronary mortality in the patients with DM 1. Total mortality is increased in patients with DM 2 and microalbuminuria with a RR of 1.8, and it is related to microalbuminuria levels even below the considered normal range (20 microg/min and/or 30 mg/day). For this reason, the definition of microalbuminuria must be reviewed in the patients with DM 2. More studies are needed to confirm the predictive power of microalbuminuria in cardiovascular and coronary disease.
摘要
早期发现糖尿病肾病很重要，因为它是一种心血管风险标志物，表明在1型糖尿病（DM 1）以及2型糖尿病（DM 2）中存在与心血管事件风险增加相关的血管变化。微量白蛋白尿是DM 1患者总体心血管和冠状动脉死亡的危险因素。DM 2和微量白蛋白尿患者的总死亡率增加，相对危险度为1.8，甚至与低于公认正常范围（20微克/分钟和/或30毫克/天）的微量白蛋白尿水平有关。因此，必须重新审视DM 2患者微量白蛋白尿的定义。需要更多研究来证实微量白蛋白尿在心血管和冠状动脉疾病中的预测能力。
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