中药治疗糖尿病肾病蛋白尿的疗效比较：一项系统评价与Meta分析
Effectiveness comparisons of traditional Chinese medicine on treating diabetic nephropathy proteinuria: A systematic review and meta-analysis.
作者信息
Wang Lin, Wang Ya-Hui, Zhang Xian-Hui, Yang Xue-Lian, Wei Hui-Li, An Zhi-Chao, Yu Bo-Rui, Du Da-Qing, Guo Yan, Liu Hong-Fang
机构信息
Nephrology Department, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing, China.
出版信息
Medicine (Baltimore). 2019 Oct;98(43):e17495. doi: 10.1097/MD.0000000000017495.
BACKGROUND
Diabetic nephropathy (DN) is one of the microvascular complications of diabetes mellitus. Proteinuria is the most important clinical feature of DN and an independent risk factor for the progression of DN. Therefore, reducing urinary protein is the primary goal of DN treatment. Traditional Chinese medicine (TCM) has long been widely used in the treatment of DN. Therefore, this paper conducted a meta-analysis of the clinical efficacy of TCM in the treatment of DN proteinuria, to comprehensively analyze the role of TCM in the treatment of DN.
METHODS
We will search for PubMed, Cochrane Library, AMED, EMbase, WorldSciNet, Nature, Science online and China Journal Full-text Database, China Biomedical Literature CD-ROM Database, and related randomized controlled trials included in the China Resources Database. The time is limited from the construction of the library to September 2019. We will use the criteria provided by Cochrane 5.1.0 for quality assessment and risk assessment of the included studies, and use the Revman 5.3 and Stata13.0 software for meta-analysis of the effectiveness, recurrence rate, and symptom scores of DN proteinuria.
TRIAL REGISTRATION NUMBER
PROSPERO CRD42019139707.
背景
糖尿病肾病（DN）是糖尿病的微血管并发症之一。蛋白尿是DN最重要的临床特征，也是DN进展的独立危险因素。因此，降低尿蛋白是DN治疗的主要目标。中医药长期以来广泛应用于DN的治疗。因此，本文对中医药治疗DN蛋白尿的临床疗效进行荟萃分析，以全面分析中医药在DN治疗中的作用。
方法
我们将检索PubMed、Cochrane图书馆、AMED、EMbase、WorldSciNet、Nature、Science在线以及中国期刊全文数据库、中国生物医学文献光盘数据库，以及华润数据库中纳入的相关随机对照试验。时间范围从建库至2019年9月。我们将使用Cochrane 5.1.0提供的标准对纳入研究进行质量评估和风险评估，并使用Revman 5.3和Stata13.0软件对DN蛋白尿的有效性、复发率和症状评分进行荟萃分析。
试验注册号
PROSPERO CRD42019139707。
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