剖析精神疾病全基因组关联研究中的表型
Dissecting the phenotype in genome-wide association studies of psychiatric illness.
作者信息
Craddock Nick, Kendler Kenneth, Neale Michael, Nurnberger John, Purcell Shaun, Rietschel Marcella, Perlis Roy, Santangelo Susan L, Schulze Thomas G, Smoller Jordan W, Thapar Anita
出版信息
Br J Psychiatry. 2009 Aug;195(2):97-9. doi: 10.1192/bjp.bp.108.063156.
Abstract
Over the past 2 years genome-wide association studies have made major contributions to understanding the genetic architecture of many common human diseases. This editorial outlines the development of such studies in psychiatry and highlights the opportunities for advancing understanding of the biological underpinnings and nosological structure of psychiatric disorders.
摘要
在过去两年中，全基因组关联研究为理解多种常见人类疾病的遗传结构做出了重大贡献。这篇社论概述了此类研究在精神病学领域的发展，并强调了增进对精神疾病生物学基础和疾病分类结构理解的机遇。
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