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剖析精神疾病全基因组关联研究中的表型

Dissecting the phenotype in genome-wide association studies of psychiatric illness.

作者信息

Craddock Nick, Kendler Kenneth, Neale Michael, Nurnberger John, Purcell Shaun, Rietschel Marcella, Perlis Roy, Santangelo Susan L, Schulze Thomas G, Smoller Jordan W, Thapar Anita

出版信息

Br J Psychiatry. 2009 Aug;195(2):97-9. doi: 10.1192/bjp.bp.108.063156.

DOI:10.1192/bjp.bp.108.063156
PMID:19648536
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4739810/
Abstract

Over the past 2 years genome-wide association studies have made major contributions to understanding the genetic architecture of many common human diseases. This editorial outlines the development of such studies in psychiatry and highlights the opportunities for advancing understanding of the biological underpinnings and nosological structure of psychiatric disorders.

摘要

在过去两年中，全基因组关联研究为理解多种常见人类疾病的遗传结构做出了重大贡献。这篇社论概述了此类研究在精神病学领域的发展，并强调了增进对精神疾病生物学基础和疾病分类结构理解的机遇。

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本文引用的文献

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Two variants in Ankyrin 3 (ANK3) are independent genetic risk factors for bipolar disorder.锚蛋白3（ANK3）中的两个变体是双相情感障碍的独立遗传风险因素。
Mol Psychiatry. 2009 May;14(5):487-91. doi: 10.1038/mp.2008.134. Epub 2008 Dec 16.
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Strong genetic evidence for a selective influence of GABAA receptors on a component of the bipolar disorder phenotype.强有力的遗传证据表明，GABAA 受体对双相情感障碍表型的一个成分具有选择性影响。
Mol Psychiatry. 2010 Feb;15(2):146-53. doi: 10.1038/mp.2008.66. Epub 2008 Jul 1.
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A framework for interpreting genome-wide association studies of psychiatric disorders.一种解读精神疾病全基因组关联研究的框架。
Mol Psychiatry. 2009 Jan;14(1):10-7. doi: 10.1038/mp.2008.126. Epub 2008 Nov 11.
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Genetic mapping in human disease.人类疾病中的基因定位
Science. 2008 Nov 7;322(5903):881-8. doi: 10.1126/science.1156409.
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Autoimmune diseases: insights from genome-wide association studies.自身免疫性疾病：全基因组关联研究的见解
Hum Mol Genet. 2008 Oct 15;17(R2):R116-21. doi: 10.1093/hmg/ddn246.
6
Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder.全基因组关联协作分析支持ANK3和CACNA1C在双相情感障碍中的作用。
Nat Genet. 2008 Sep;40(9):1056-8. doi: 10.1038/ng.209.
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Identification of loci associated with schizophrenia by genome-wide association and follow-up.通过全基因组关联研究及随访确定与精神分裂症相关的基因座
Nat Genet. 2008 Sep;40(9):1053-5. doi: 10.1038/ng.201.
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Rethinking psychosis: the disadvantages of a dichotomous classification now outweigh the advantages.重新思考精神病：二分法分类的弊端现在超过了其优势。
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