Department of Psychiatry, McKusick Nathans Institute of Genetic Medicine, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.
Psychiatr Clin North Am. 2010 Mar;33(1):1-13. doi: 10.1016/j.psc.2009.12.006.
The practice of psychiatry has long suffered from the limited information available on the biological basis of mental disorders. This limitation is now coming to an end. Advances in DNA analysis technologies and in our understanding of the human genome, together with our new knowledge of the properties of the genome and significant efforts toward generating large patient and control sample collections, have paved the way for successful genome-wide association studies. As a result, reports now appear in the literature every week identifying new genes for complex disorders. Next-generation sequencing methods, combined with the results of association and perhaps linkage studies, will help us uncover missing heritability factors, achieve a better understanding of the genetic aspects of psychiatric disease, and devise the best strategies for incorporating genetics in the service of patients.
精神病学的实践长期以来一直受到精神障碍生物学基础可用信息的限制。这种限制现在即将结束。DNA 分析技术的进步和我们对人类基因组的理解，以及我们对基因组特性的新知识和生成大型患者和对照样本集的巨大努力，为全基因组关联研究铺平了道路。结果，现在每周文献中都会有报告确定复杂疾病的新基因。与关联研究，也许还有连锁研究的结果相结合的下一代测序方法将帮助我们发现缺失的遗传因素，更好地理解精神疾病的遗传方面，并制定将遗传学纳入患者服务的最佳策略。
