Intensive Care Unit, Austin Hospital, Heidelberg, Vic, Australia.
Blood Purif. 2009;28(3):216-25. doi: 10.1159/000230813. Epub 2009 Jul 31.
In the critically ill, ischemia secondary to decreased renal blood flow (RBF) is believed to be central to the pathogenesis of acute renal failure (ARF); however, the scientific basis for this conclusion has not been systematically evaluated.
Systematic interrogation of the Pubmed database, and screening bibliographies of retrieved reports, for studies of human ARF where RBF was measured.
Thirty-two articles published between 1944 and 2008 describing RBF in 373 patients with ARF were identified. Overall, mean RBF during ARF was 387 ml/min. It was 329 ml/min when estimated by clearance-based techniques (15 studies) and 471 ml/min when measured with nonclearance-based techniques (17 studies). Only 46 patients had measurements in the intensive care unit where mean RBF was 306 ml/min. Normal RBF was reported in 14 publications, mean 1,192 ml/min.
Limited information is available on RBF during ARF in the critically ill. Measurements in contemporary patients are required to further our understanding of this condition.
在危重病患者中，由于肾血流量（RBF）减少引起的缺血被认为是急性肾衰竭（ARF）发病机制的核心；然而，这一结论的科学依据尚未得到系统评估。
系统查询 Pubmed 数据库，并筛选检索报告的参考文献，以获取研究 ARF 中测量 RBF 的研究。
在 1944 年至 2008 年间发表的 32 篇文章中，描述了 373 例 ARF 患者的 RBF。总体而言，ARF 期间的平均 RBF 为 387ml/min。通过基于清除率的技术（15 项研究）估计的 RBF 为 329ml/min，而通过非基于清除率的技术（17 项研究）测量的 RBF 为 471ml/min。只有 46 名患者在重症监护病房进行了测量，平均 RBF 为 306ml/min。在 14 篇出版物中报告了正常 RBF，平均为 1192ml/min。
目前有关危重病患者 ARF 期间 RBF 的信息有限。需要对当代患者进行测量，以进一步了解这种情况。
