Menon G K, Kligman A M
Global R&D, ISP Corporation, Wayne, NJ 07470, USA.
Skin Pharmacol Physiol. 2009;22(4):178-89. doi: 10.1159/000231523. Epub 2009 Jul 31.
The fascinating topic of skin barrier continues to engage researchers from diverse disciplines both in academia and industry. Much of the information on the basic biology of barrier formation, its ontogeny as well as repair and homeostasis comes from studies on animal models. A smaller number of human studies have validated the usefulness of animal models, while highlighting some essential differences. We submit that the human skin barrier is unique in several ways, as much due to our adaptive ability as our control over the environment (macro and micro) that none of the other species have exerted. The human skin is not only exposed to the greatest variations of environment due to our phenomenal mobility but also to the largest number of xenobiotics, both chemical and microbial, resulting from human activity. In this overview, we attempt to evaluate the interdependent relation of skin barriers to environmental stressors hoping to raise interest in some of the lesser known or neglected aspects of human skin barriers as they relate to skin health and dysfunctions.
皮肤屏障这一引人入胜的话题持续吸引着学术界和工业界不同学科的研究人员。关于屏障形成的基础生物学、其个体发育以及修复和稳态的许多信息都来自对动物模型的研究。较少数量的人体研究验证了动物模型的实用性，同时也突出了一些本质差异。我们认为，人类皮肤屏障在几个方面具有独特性，这既归因于我们的适应能力，也归因于我们对环境（宏观和微观）的控制，而其他物种均未施加过这种控制。由于我们惊人的移动性，人类皮肤不仅暴露于最大程度的环境变化中，还暴露于因人类活动产生的数量最多的化学和微生物等外源性物质中。在本综述中，我们试图评估皮肤屏障与环境应激源之间的相互依存关系，希望能引起人们对人类皮肤屏障中一些鲜为人知或被忽视的方面的关注，因为它们与皮肤健康和功能障碍相关。
