Kim Sung Tae
Department of Pharmaceutical Engineering, Inje University, Gimhae 50834, Republic of Korea.
Department of Nanoscience and Engineering, Inje University, Gimhae 50834, Republic of Korea.
Pharmaceutics. 2025 Aug 7;17(8):1024. doi: 10.3390/pharmaceutics17081024.
Polynucleotide (PN) and polydeoxyribonucleotide (PDRN) are DNA-derived biopolymers increasingly recognized for their potential in dermatology. Despite their structural similarities, PN and PDRN exhibit distinct functions due to differences in polymer length and molecular weight. PN, composed of longer DNA fragments, plays a key role in extracellular matrix remodeling. Conversely, PDRN, composed of relatively shorter oligonucleotide sequences than those of PN, enhances skin condition through adenosine receptor activations and supports nucleotide synthesis via both the salvage and de novo pathways. This review provides a critical comparison of the molecular characteristics and functions of PN and PDRN with particular emphasis on their dermatological applications. By delineating their respective roles in esthetic and regenerative medicine, we aim to highlight recent advances that may guide the development of optimized treatment strategies and foster evidence-based clinical practice.
多核苷酸（PN）和聚脱氧核糖核苷酸（PDRN）是源自DNA的生物聚合物，其在皮肤病学中的潜力越来越受到认可。尽管它们在结构上有相似之处，但由于聚合物长度和分子量的差异，PN和PDRN表现出不同的功能。由较长DNA片段组成的PN在细胞外基质重塑中起关键作用。相反，PDRN由比PN相对较短的寡核苷酸序列组成，通过腺苷受体激活来改善皮肤状况，并通过补救途径和从头合成途径支持核苷酸合成。本综述对PN和PDRN的分子特征和功能进行了批判性比较，特别强调了它们在皮肤病学中的应用。通过阐述它们在美容医学和再生医学中的各自作用，我们旨在突出近期的进展，这些进展可能指导优化治疗策略的开发并促进循证临床实践。
