轴突生长刺激包包括局部翻译。
Axon growth-stimulus package includes local translation.
作者信息
Macara Ian G, Iioka Hidekazu, Mili Stavroula
机构信息
Ian G. Macara, Hidekazu Iioka and Stavroula Mili are in the Center for Cell Signaling, University of Virginia, Charlottesville, VA 22908-0577, USA.
出版信息
Nat Cell Biol. 2009 Aug;11(8):919-21. doi: 10.1038/ncb0809-919.
Abstract
Translation of localized mRNAs is an important mechanism for controlling spatially discrete cellular processes. The polarity protein Par-3 is locally translated in axons in response to factors such as NGF and netrin-1, and this increased expression is necessary for factor-stimulated axonal outgrowth.
摘要
局部化信使核糖核酸的翻译是控制空间离散细胞过程的重要机制。极性蛋白Par-3响应神经生长因子（NGF）和网蛋白-1等因子在轴突中进行局部翻译，而这种表达增加对于因子刺激的轴突生长是必要的。
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3
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