Macara Ian G, Iioka Hidekazu, Mili Stavroula
Ian G. Macara, Hidekazu Iioka and Stavroula Mili are in the Center for Cell Signaling, University of Virginia, Charlottesville, VA 22908-0577, USA.
Nat Cell Biol. 2009 Aug;11(8):919-21. doi: 10.1038/ncb0809-919.
Translation of localized mRNAs is an important mechanism for controlling spatially discrete cellular processes. The polarity protein Par-3 is locally translated in axons in response to factors such as NGF and netrin-1, and this increased expression is necessary for factor-stimulated axonal outgrowth.
局部化信使核糖核酸的翻译是控制空间离散细胞过程的重要机制。极性蛋白Par-3响应神经生长因子（NGF）和网蛋白-1等因子在轴突中进行局部翻译，而这种表达增加对于因子刺激的轴突生长是必要的。
