Fontanesi Luca, Scotti Emilio, Buttazzoni Luca, Dall'Olio Stefania, Bagnato Alessandro, Lo Fiego Domenico Pietro, Davoli Roberta, Russo Vincenzo
DIPROVAL, Sezione di Allevamenti Zootecnici, Faculty of Agriculture, University of Bologna, Reggio Emilia, Italy.
Mol Biol Rep. 2010 Jan;37(1):461-6. doi: 10.1007/s11033-009-9638-8. Epub 2009 Aug 1.
We recently showed that a polymorphism in the fat mass and obesity associated (FTO) gene (AM931150: g.276T > G) is associated with fat deposition traits in pigs. To confirm this result, we genotyped this polymorphism in an Italian Duroc population made up by 313 performance tested pigs with known estimated breeding values (EBVs) for average daily gain, back fat thickness (BFT), feed:gain ratio, lean cuts (LC), and visible intermuscular fat (VIF, a measure of intermuscular fat in the hams). In addition, we genotyped 148 commercial heavy pigs for which several fat deposition traits and lean meat percentage were measured. The results of the association analyses confirmed the effect of the FTO mutation on obesity-related traits (VIF, BFT and LC) in the Italian Duroc pigs (P < 0.01) and in the commercial pigs (intramuscular fat content of different muscles, P < 0.05 or P < 0.10; lean meat content, P < 0.05; BFT, P < 0.05; intermuscular fat content in the hams, P < 0.05).
我们最近发现，脂肪量和肥胖相关（FTO）基因中的一个多态性（AM931150：g.276T>G）与猪的脂肪沉积性状相关。为了证实这一结果，我们对一个意大利杜洛克猪群体中的该多态性进行了基因分型，该群体由313头经过性能测试的猪组成，这些猪具有已知的平均日增重、背膘厚度（BFT）、料重比、瘦肉切块（LC）和可见肌间脂肪（VIF，火腿中肌间脂肪的一种度量）的估计育种值（EBV）。此外，我们对148头商业重型猪进行了基因分型，测量了它们的几个脂肪沉积性状和瘦肉率。关联分析结果证实了FTO突变对意大利杜洛克猪（P<0.01）和商业猪（不同肌肉的肌内脂肪含量，P<0.05或P<0.10；瘦肉含量，P<0.05；BFT，P<0.05；火腿中的肌间脂肪含量，P<0.05）肥胖相关性状（VIF、BFT和LC）的影响。
