Jones R M, Bulaj G
Cognetix Inc, Department of Medicinal Chemistry, Salt Lake City, UT-84108, USA.
Curr Opin Drug Discov Devel. 2000 Mar;3(2):141-54.
Conotoxins, the disulfide-rich toxin components of venomous marine cone snails, have attracted a great deal of attention in recent years because of their demonstrated pharmacological receptor subtype selectivities and distinct potential for development as new central nervous system (CNS) therapeutics. This review highlights some of the recent advancements in this field and describes a selection of contemporary papers pertaining to regioselective strategies for the synthesis of disulfide bridges in conotoxins, as well as other small constrained peptides. Primarily, we have covered papers that have appeared in the scientific literature over the past two years. A number of comprehensive conotoxin literature reviews have appeared in recent times.
芋螺毒素是有毒海洋芋螺毒液中富含二硫键的毒素成分，近年来因其已证实的药理受体亚型选择性以及作为新型中枢神经系统（CNS）治疗药物的独特开发潜力而备受关注。本综述重点介绍了该领域的一些最新进展，并描述了一系列与芋螺毒素及其他小分子受限肽中二硫键合成的区域选择性策略相关的当代论文。主要而言，我们涵盖了过去两年发表在科学文献中的论文。近期出现了许多全面的芋螺毒素文献综述。
