Bronner W, Nyman P, von Minden D
Division of Forensic Toxicology, Armed Forces Institute of Pathology, Washington, D.C. 20306-6000.
J Anal Toxicol. 1990 Nov-Dec;14(6):368-71. doi: 10.1093/jat/14.6.368.
The ability to alter immunoassay test results by the addition of some commonly available chemicals to drug-positive and drug-negative urine specimens was investigated. Urine specimens containing either phencyclidine (PCP) or 11-nor-delta 9-tetrahydrocannabinol-9-carboxylic acid (9-THC-COOH) were adulterated with sodium chloride, bleach, vinegar, potassium hydroxide, liquid soap, 2-propanol, and ammonia. Subsequent analyses by radioimmunoassay (RIA) and fluorescence polarization immunoassay (FPIA) demonstrated false positive and false negative results with some adulterants. Radioimmunoassay false positives occurred with potassium hydroxide (PCP and THC-COOH assays) and bleach (THC-COOH assay) adulterants. Bleach (PCP assay) and soap (THC-COOH assay) additives resulted in false negative analyses by RIA. No adulterant caused FPIA false positives. FPIA false negatives occurred with bleach (PCP and THC-COOH assays) and potassium hydroxide (PCP assay) adulterants.
研究了通过向药物阳性和药物阴性尿液标本中添加一些常见化学品来改变免疫分析测试结果的能力。含有苯环己哌啶（PCP）或11-去甲-δ9-四氢大麻酚-9-羧酸（9-THC-COOH）的尿液标本用氯化钠、漂白剂、醋、氢氧化钾、液体肥皂、2-丙醇和氨进行掺假。随后通过放射免疫分析（RIA）和荧光偏振免疫分析（FPIA）进行的分析表明，某些掺假物会导致假阳性和假阴性结果。氢氧化钾（PCP和THC-COOH分析）和漂白剂（THC-COOH分析）掺假物会导致RIA出现假阳性。漂白剂（PCP分析）和肥皂（THC-COOH分析）添加剂会导致RIA分析出现假阴性。没有掺假物导致FPIA出现假阳性。漂白剂（PCP和THC-COOH分析）和氢氧化钾（PCP分析）掺假物会导致FPIA出现假阴性。
