Process optimization with in situ technologies.

In situ technologies coupled with automated laboratory reaction systems are significantly improving the way we optimize and scale-up chemical processes. In situ analytical probes are ideal for the continuous monitoring of chemical and physical changes without disturbing the reaction environment, thereby eliminating questions of sample integrity. In manufacturing settings, these tools can offer advantages of increased efficiency, safety and cost savings. This review will discuss approaches to process development and highlight important recent contributions of in situ technologies and automated systems impacting process optimization for pharmaceutical development.