Rein A J, Donahue S M, Pavlosky M A
ASI Applied Systems Inc (a Mettler Toledo company), Millersville, MD 21108, USA.
Curr Opin Drug Discov Devel. 2000 Nov;3(6):734-42.
The potential for the production of increasing numbers of drug candidates as a result of combinatorial techniques, coupled with the necessity of striving for safer, more efficient processes, poses a special challenge and opportunity to the development chemist and engineer. In support of this quest for better molecules and processes, in situ analytical methodologies are becoming an ever-important ally. In particular, in situ FTIR spectroscopy is providing a wealth of information about reaction kinetics, pathways and mechanisms for a wide range of chemistry in both academic and industrial laboratories. This review article provides an historic perspective on the use of in situ FTIR spectroscopy and covers the recent literature published as a variety of pharmaceutical-related topics.
组合技术使得候选药物数量不断增加，同时需要努力实现更安全、更高效的工艺，这给药物研发化学家和工程师带来了特殊的挑战与机遇。为了助力研发出更好的分子和工艺，原位分析方法正成为越来越重要的帮手。特别是，原位傅里叶变换红外光谱（FTIR）正在为学术和工业实验室中的各类化学反应动力学、反应途径及反应机理提供丰富信息。本文综述了原位FTIR光谱的应用历史，并涵盖了近期发表的各种与制药相关主题的文献。
