Chinaglia G, Probst A, Palacios J M
Department of Pathology, University of Basel, Switzerland.
Neuroscience. 1990;39(2):351-60. doi: 10.1016/0306-4522(90)90273-7.
The technique of receptor autoradiography was used to study the distribution of neurotensin receptors in post mortem brain tissues from patients affected by Parkinson's disease, progressive supranuclear palsy and from age-matched controls. [125I]Neurotensin was used as ligand. Significant receptor decreases were found in the substantia nigra, both pars compacta and reticulata, and in the putamen in Parkinson's disease and progressive supranuclear palsy. In addition, significant decreases of neurotensin receptors were found in the ventral tegmental area, nucleus accumbens and dorsal part of caudate head in patients with Parkinson's disease but not in patients with progressive supranuclear palsy, indicating differential involvement of neurotensin receptors in these two neurological disorders. In addition, both in Parkinson's disease and progressive supranuclear palsy the decrement of striatal neurotensin binding sites was less than expected from the reported decrease of dopamine content in this nucleus, suggesting only partial localization of neurotensin receptors on mesostriatal dopaminergic projections.
采用受体放射自显影技术，研究帕金森病、进行性核上性麻痹患者以及年龄匹配的对照者死后脑组织中神经降压素受体的分布情况。以[125I]神经降压素作为配体。在帕金森病和进行性核上性麻痹患者中，黑质致密部和网状部以及壳核的受体显著减少。此外，帕金森病患者的腹侧被盖区、伏隔核和尾状核头部背侧的神经降压素受体显著减少，而进行性核上性麻痹患者则未出现这种情况，这表明神经降压素受体在这两种神经系统疾病中的受累情况不同。此外，在帕金森病和进行性核上性麻痹中，纹状体神经降压素结合位点的减少均低于该核中多巴胺含量报道的减少量，提示神经降压素受体仅部分定位于中脑纹状体多巴胺能投射上。
