• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Parkinson's disease: depletion of substantia nigra neurotensin receptors.

作者信息

Uhl G R, Whitehouse P J, Price D L, Tourtelotte W W, Kuhar M J

出版信息

Brain Res. 1984 Aug 6;308(1):186-90. doi: 10.1016/0006-8993(84)90935-1.

DOI:10.1016/0006-8993(84)90935-1
PMID:6089953
Abstract

Neurotensin receptor autoradiography reveals dense binding in normal human substantia nigra. In nigra from patients with Parkinson's disease, nigral receptor binding is only about one-third of control values. 'Saturation' analysis suggests that these changes result from receptor loss. These results support a neurotensin-dopamine interaction in human nigro-striatal circuits.

摘要

相似文献

1
Parkinson's disease: depletion of substantia nigra neurotensin receptors.
Brain Res. 1984 Aug 6;308(1):186-90. doi: 10.1016/0006-8993(84)90935-1.
2
Loss of high affinity neurotensin receptors in substantia nigra from parkinsonian subjects.
Biochem Biophys Res Commun. 1984 Nov 30;125(1):395-404. doi: 10.1016/s0006-291x(84)80381-2.
3
Regulation of neurotensin-containing neurons in the rat striatum and substantia nigra. Effects of unilateral nigral lesion with 6-hydroxydopamine on neurotensin content and its binding site density.大鼠纹状体和黑质中含神经降压素神经元的调节。6-羟基多巴胺单侧黑质损伤对神经降压素含量及其结合位点密度的影响。
Brain Res. 1990 Mar 5;510(2):203-10. doi: 10.1016/0006-8993(90)91368-q.
4
Neurotensin receptors in Parkinson's disease and progressive supranuclear palsy: an autoradiographic study in basal ganglia.帕金森病和进行性核上性麻痹中的神经降压素受体：基底神经节的放射自显影研究
Neuroscience. 1990;39(2):351-60. doi: 10.1016/0306-4522(90)90273-7.
5
Parkinson's disease: nigral receptor changes support peptidergic role in nigrostriatal modulation.帕金森病：黑质受体变化支持肽能在黑质纹状体调节中的作用。
Ann Neurol. 1986 Aug;20(2):194-203. doi: 10.1002/ana.410200204.
6
Heterogeneity of melanized neurons expressing neurotensin receptor messenger RNA in the substantia nigra and the nucleus paranigralis of control and Parkinson's disease brain.对照和帕金森病大脑黑质及黑质旁核中表达神经降压素受体信使核糖核酸的黑素化神经元的异质性
Neuroscience. 1995 Jan;64(2):405-17. doi: 10.1016/0306-4522(94)00395-l.
7
Alteration of neurotensin receptors in MPTP-treated mice.
Peptides. 1999;20(7):803-7. doi: 10.1016/s0196-9781(99)00065-0.
8
Chronic neuroleptic treatment enhances neurotensin receptor binding in human and rat substantia nigra.长期使用抗精神病药物治疗可增强人和大鼠黑质中神经降压素受体的结合。
Nature. 1984;309(5966):350-2. doi: 10.1038/309350a0.
9
Regional distribution of monoamine vesicular uptake sites in the mesencephalon of control subjects and patients with Parkinson's disease: a postmortem study using tritiated tetrabenazine.对照组和帕金森病患者中脑单胺囊泡摄取位点的区域分布：一项使用氚标记丁苯那嗪的尸检研究
Brain Res. 1995 Sep 18;692(1-2):233-43. doi: 10.1016/0006-8993(95)00674-f.
10
Morphological substrate for neurotensin-dopamine interactions in the rat midbrain tegmentum.大鼠中脑被盖区神经降压素-多巴胺相互作用的形态学基础。
Ann N Y Acad Sci. 1992;668:173-85. doi: 10.1111/j.1749-6632.1992.tb27349.x.

引用本文的文献

1
Demystifying the Neuroprotective Role of Neuropeptides in Parkinson's Disease: A Newfangled and Eloquent Therapeutic Perspective.揭开神经肽在帕金森病中神经保护作用的神秘面纱：一种新颖而雄辩的治疗视角。
Int J Mol Sci. 2022 Apr 20;23(9):4565. doi: 10.3390/ijms23094565.
2
The Emerging Role of Neuropeptides in Parkinson's Disease.神经肽在帕金森病中的新作用
Front Aging Neurosci. 2021 Mar 8;13:646726. doi: 10.3389/fnagi.2021.646726. eCollection 2021.
3
Neuroprotective Effects of Brain-Gut Peptides: A Potential Therapy for Parkinson's Disease.
脑肠肽的神经保护作用：帕金森病的潜在治疗方法。
Neurosci Bull. 2019 Dec;35(6):1085-1096. doi: 10.1007/s12264-019-00407-3. Epub 2019 Jul 8.
4
Regional and Cellular Mapping of Sortilin Immunoreactivity in Adult Human Brain.成年人类大脑中sortilin免疫反应性的区域和细胞定位
Front Neuroanat. 2019 Mar 12;13:31. doi: 10.3389/fnana.2019.00031. eCollection 2019.
5
Preventive Effect of Two New Neurotensin Analogues on Parkinson's Disease Rat Model.两种新型神经降压素类似物对帕金森病大鼠模型的预防作用。
J Mol Neurosci. 2018 Dec;66(4):552-560. doi: 10.1007/s12031-018-1171-6. Epub 2018 Oct 30.
6
Neurotensin-polyplex-mediated brain-derived neurotrophic factor gene delivery into nigral dopamine neurons prevents nigrostriatal degeneration in a rat model of early Parkinson's disease.神经降压素-多聚体介导的脑源性神经营养因子基因导入黑质多巴胺能神经元可预防早期帕金森病大鼠模型的黑质纹状体变性。
J Biomed Sci. 2015 Jul 22;22(1):59. doi: 10.1186/s12929-015-0166-7.
7
The role of neurotensin in central nervous system pathophysiology: what is the evidence?神经降压素在中枢神经系统病理生理学中的作用：证据有哪些？
J Psychiatry Neurosci. 2006 Jul;31(4):229-45.
8
Regulatory peptide receptors: visualization by autoradiography.
Experientia. 1987 Jul 15;43(7):750-61. doi: 10.1007/BF01945352.
9
Dopaminergic control of 125I-labeled neurotensin binding site density in corticolimbic structures of the rat brain.多巴胺能对大鼠大脑皮质边缘结构中125I标记的神经降压素结合位点密度的调控
Proc Natl Acad Sci U S A. 1986 Aug;83(16):6203-7. doi: 10.1073/pnas.83.16.6203.
10
Human serum Cohn fraction IV (alpha-globulin [correction of globin] enriched) inhibits ligand binding at neurotransmitter receptors in human brain.人血清科恩IV组分（富含α球蛋白[球蛋白校正]）可抑制人脑神经递质受体处的配体结合。
Proc Natl Acad Sci U S A. 1986 Jun;83(12):4572-5. doi: 10.1073/pnas.83.12.4572.