Baxevanis Constantin N, Perez Sonia A, Papamichail Michael
Cancer Immunology and Immunotherapy Center, Saint Savas Cancer Hospital, Athens, Greece.
Crit Rev Clin Lab Sci. 2009;46(4):167-89. doi: 10.1080/10408360902937809.
Recent scientific advances have expanded our understanding of the immune system and its response to malignant cells. The clinical goal of tumour immunotherapy is to provide either passive or active immunity against malignancies by harnessing the immune system to target tumours. Monoclonal antibodies, cytokines, cellular immunotherapy, and vaccines have increasingly become successful therapeutic agents for the treatment of solid and haematological cancers in preclinical models, clinical trials, and practice. In this article, we review recent advances in the immunotherapy of cancer, focusing on new strategies and future perspectives as well as on clinical trials attempting to enhance the efficacy of immunotherapeutic modalities and translate this knowledge into effective cancer therapies.
近期的科学进展拓展了我们对免疫系统及其对恶性细胞反应的理解。肿瘤免疫疗法的临床目标是通过利用免疫系统靶向肿瘤，提供针对恶性肿瘤的被动或主动免疫。单克隆抗体、细胞因子、细胞免疫疗法和疫苗在临床前模型、临床试验及实际应用中，已日益成为治疗实体瘤和血液系统癌症的成功治疗手段。在本文中，我们综述了癌症免疫疗法的近期进展，重点关注新策略和未来前景，以及旨在提高免疫治疗方式疗效并将这一知识转化为有效癌症治疗方法的临床试验。
