Cao B J, Chen Z K, Chi Z Q
Department of Pharmacology, Wenzhou Medical College, China.
Zhongguo Yao Li Xue Bao. 1990 May;11(3):207-10.
The neuromuscular blocking and respiratory depressing actions of the new insecticide sodium ammonium dimethyl-2-(propano-1,3-dithiosulfate) monohydrate (SCD) were investigated. In peroneal-tibialis anterior nerve-muscle preparations of urethane anesthetized rabbit, SCD 6.5 mg/kg iv completely depressed the indirectly elicited twitch tension but not the directly elicited one. This compound also caused initial potentiation of the indirectly elicited twitch tension. In the partially paralyzed preparations, potentiation of contractions occurred following a brief period of indirectly tetanic stimulation. Nereistoxin but not SCD blocked the indirectly elicited twitch tension of isolated rat diaphragm. The neuromuscular blockade induced by SCD and nereistoxin was antagonized by neostigmine and 4-aminopyridine. SCD and nereistoxin had little or no effect on arterial blood pressure and phrenic nerve discharge of rabbits. The results indicated that SCD-poisoned rabbits died of respiratory paralysis following the neuromuscular blockade.
对新型杀虫剂二甲基-2-（1,3-二硫代丙酸酯）一水合铵钠（SCD）的神经肌肉阻断和呼吸抑制作用进行了研究。在氨基甲酸乙酯麻醉的兔的腓骨-胫前神经-肌肉标本中，静脉注射6.5mg/kg的SCD可完全抑制间接诱发的抽搐张力，但不抑制直接诱发的抽搐张力。该化合物还引起间接诱发的抽搐张力的初始增强。在部分麻痹的标本中，在短暂的间接强直刺激后，收缩增强。沙蚕毒素可阻断离体大鼠膈肌间接诱发的抽搐张力，但SCD无此作用。新斯的明和4-氨基吡啶可拮抗SCD和沙蚕毒素诱导的神经肌肉阻断。SCD和沙蚕毒素对兔的动脉血压和膈神经放电几乎没有影响。结果表明，SCD中毒的兔在神经肌肉阻断后死于呼吸麻痹。
