Koide Y, Yoshida T O
Department of Microbiology and Immunology, Hamamatsu University School of Medicine, Japan.
Int Immunol. 1990;2(2):189-92. doi: 10.1093/intimm/2.2.189.
It is generally held that one of the recessive genes controlling diabetes in the NOD mouse is linked to the major histocompatibility complex (MHC). Unique substitution of Asp57 with Ser in the A beta chain is considered to make the A beta gene the MHC-linked susceptibility gene. We therefore analysed the nucleotide sequences of the A beta second exon in ILI, CTS, and NON mice, which are nondiabetic inbred strains but are derived from the same Jcl-ICR mice as the NOD mouse. The DNA sequence analyses revealed that the A beta second exon sequences in the ILI and CTS mice, but not in the NON mouse, are identical to that of the NOD mouse. Possible roles of Ser57 of the A beta chain in the nondiabetic sister strains are discussed.
一般认为，控制非肥胖糖尿病（NOD）小鼠糖尿病的隐性基因之一与主要组织相容性复合体（MHC）相关联。β-淀粉样蛋白（Aβ）链中第57位天冬氨酸被丝氨酸独特取代被认为使Aβ基因成为与MHC相关的易感基因。因此，我们分析了ILI、CTS和NON小鼠中Aβ第二外显子的核苷酸序列，这些是无糖尿病的近交系小鼠，但与NOD小鼠一样源自相同的Jcl-ICR小鼠。DNA序列分析显示，ILI和CTS小鼠而非NON小鼠中的Aβ第二外显子序列与NOD小鼠的相同。讨论了Aβ链中丝氨酸57在非糖尿病姐妹品系中的可能作用。
