非肥胖型糖尿病（NOD）小鼠：主要组织相容性复合体中的隐性致糖尿病基因。

The NOD mouse: recessive diabetogenic gene in the major histocompatibility complex.

作者信息

Hattori M, Buse J B, Jackson R A, Glimcher L, Dorf M E, Minami M, Makino S, Moriwaki K, Kuzuya H, Imura H

出版信息

Science. 1986 Feb 14;231(4739):733-5. doi: 10.1126/science.3003909.

Abstract

Examination of the histocompatibility region of the nonobese diabetic (NOD) mouse with antibodies against class II glycoproteins (products of immune response genes of the major histocompatibility complex I-A and I-E), hybrid T-cell clones, and mixed-lymphocyte cultures and analysis of restriction fragment length polymorphisms indicate that the NOD mouse has a unique class II major histocompatibility complex with no expression of surface I-E, no messenger RNA for I-E alpha, and an I-A not recognized by any monoclonal antibodies or hybrid T-cell clones studied. In crosses of NOD mice with control C3H mice, the development of diabetes was dependent on homozygosity for the NOD mouse's unique major histocompatibility region.

摘要

用抗Ⅱ类糖蛋白（主要组织相容性复合体I-A和I-E的免疫反应基因产物）的抗体、杂交T细胞克隆以及混合淋巴细胞培养物对非肥胖糖尿病（NOD）小鼠的组织相容性区域进行检测，并对限制性片段长度多态性进行分析，结果表明，NOD小鼠具有独特的Ⅱ类主要组织相容性复合体，其表面I-E无表达，无I-Eα的信使核糖核酸，且所研究的任何单克隆抗体或杂交T细胞克隆均无法识别其I-A。在NOD小鼠与对照C3H小鼠的杂交中，糖尿病的发生取决于NOD小鼠独特的主要组织相容性区域的纯合性。