Griffin Maura, Nicolaides Andrew, Tyllis Theodosis, Georgiou Niki, Martin Richard M, Bond Dawn, Panayiotou Andrie, Tziakouri Chrysa, Doré Caroline J, Fessas Charris
Vascular Noninvasive Screening and Diagnostic Centre, London, UK.
Vasc Med. 2009 Aug;14(3):227-32. doi: 10.1177/1358863X08101542.
The Cyprus Study is a prospective cohort study of cardiovascular disease (CVD). Its aim is to determine the relationship of intima-media thickness (IMT) of the common carotid (IMTcc), maximum thickness of IMT in the carotid bifurcation (IMTmax), number of carotid and femoral bifurcations with plaque and total plaque thickness (TPT) (sum of the maximum plaque measurements taken from the four bifurcations scanned) with the prevalence of clinical CVD. A total of 767 individuals (46% male) over the age of 40 years were recruited from a mountain village and a town outside the capital Nicosia. In addition to clinical examination, carotid and common femoral bifurcations were scanned with ultrasound. After controlling for conventional risk factors, there was little evidence of an association of IMTcc with CVD prevalence. However, IMTmax and TPT were associated with 2.9-fold (1.22 to 7.07) and 6.87-fold (2.42 to 19.43) increased odds of CVD prevalence, respectively. In conclusion, the TPT and number of bifurcations with plaque are more strongly associated with the prevalence of CVD. These findings warrant investigation in prospective studies to document associations with incident CVD events.
塞浦路斯研究是一项关于心血管疾病（CVD）的前瞻性队列研究。其目的是确定颈总动脉内膜中层厚度（IMTcc）、颈动脉分叉处IMT的最大厚度（IMTmax）、伴有斑块的颈动脉和股动脉分叉数量以及总斑块厚度（TPT，即从扫描的四个分叉处获取的最大斑块测量值之和）与临床CVD患病率之间的关系。从首都尼科西亚以外的一个山村和一个城镇招募了总共767名40岁以上的个体（46%为男性）。除了临床检查外，还用超声对颈动脉和股总动脉分叉处进行扫描。在控制了传统危险因素后，几乎没有证据表明IMTcc与CVD患病率有关联。然而，IMTmax和TPT分别与CVD患病率增加2.9倍（1.22至7.07）和6.87倍（2.42至19.43）的几率相关。总之，TPT和伴有斑块的分叉数量与CVD患病率的关联更强。这些发现值得在前瞻性研究中进行调查，以记录与新发CVD事件的关联。
