多酚类化合物光甘草定对低密度脂蛋白氧化的抗氧化作用。

Antioxidant effect of polyphenolic glabridin on LDL oxidation.

作者信息

Carmeli E, Fogelman Y

机构信息

Physical Therapy, Tel Aviv University, Tel Aviv, Israel.

出版信息

Toxicol Ind Health. 2009 May-Jun;25(4-5):321-4. doi: 10.1177/0748233709103034.

DOI:10.1177/0748233709103034

PMID:19651803

Abstract

This study was conducted to determine the effect of a natural polyphenolic isoflavone antioxidant (Glabridin) on low-density lipoprotein (LDL) oxidation. Determination of the extent of LDL oxidation was done by measuring the formation of Thiobarbituric acid reactive substances (TBARS). After oral administration of licorice-root ethanol extract to healthy subjects for 6 months, the subjects' oxidative stress level as well as plasma LDL oxidation reduced by 20%. We concluded that dietary consumption of glabridin protects LDL from oxidation.

摘要

本研究旨在确定一种天然多酚类异黄酮抗氧化剂（光甘草定）对低密度脂蛋白（LDL）氧化的影响。通过测量硫代巴比妥酸反应性物质（TBARS）的形成来确定LDL氧化的程度。在健康受试者口服甘草根乙醇提取物6个月后，受试者的氧化应激水平以及血浆LDL氧化降低了20%。我们得出结论，饮食中摄入光甘草定可保护LDL免受氧化。