花干细胞的终结者。
A terminator of floral stem cells.
作者信息
Ming Feng, Ma Hong
机构信息
State Key Laboratory of Genetic Engineering and Institute of Plant Biology, School of Life Sciences, Fudan University, Shanghai, China.
出版信息
Genes Dev. 2009 Aug 1;23(15):1705-8. doi: 10.1101/gad.1834409.
Abstract
Normal flower development requires the termination of stem cell activities in the floral meristem. The floral regulator AGAMOUS (AG) is necessary for this termination and represses the expression of the stem cell determinant WUSCHEL (WUS), but the repression mechanism was not clear. A recent study by Sun and colleagues (pp. 1791-1804) in this issue of Genes & Development has identified a direct target of AG, KNUCKLES (KNU), which encodes a transcriptional repressor of WUS, providing a key missing link in floral meristem determinacy.
摘要
正常的花发育需要终止花分生组织中的干细胞活性。花调控因子AGAMOUS（AG）对于这种终止是必需的，并且抑制干细胞决定因子WUSCHEL（WUS）的表达，但其抑制机制尚不清楚。Sun及其同事在本期《基因与发育》（第1791 - 1804页）上发表的一项最新研究，确定了AG的一个直接靶标KNUCKLES（KNU），它编码WUS的转录抑制因子，为花分生组织决定性提供了关键的缺失环节。
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