Messerschmitt Patrick J, Garcia Ryan M, Abdul-Karim Fadi W, Greenfield Edward M, Getty Patrick J
Department of Orthopaedic Surgery, University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, OH 44106, USA.
J Am Acad Orthop Surg. 2009 Aug;17(8):515-27. doi: 10.5435/00124635-200908000-00005.
Osteosarcoma, the most common bone sarcoma, affects approximately 560 children and adolescents annually in the United States. The incidence of new diagnoses peaks in the second decade of life. Twenty percent of patients present with clinically detectable metastases, with micrometastases presumed to be present in many of the remaining patients. Treatment typically includes preoperative chemotherapy, surgical resection, and postoperative chemotherapy. Limb-salvage procedures with wide surgical margins are the mainstay of surgical intervention. Advances in chemotherapy protocols have led to a 5-year survival rate of 60% to 78%. Among the goals of future treatment regimens are improved chemotherapeutic agents with higher specificity and lower toxicity.
骨肉瘤是最常见的骨肉瘤，在美国每年约有560名儿童和青少年受其影响。新诊断病例的发病率在生命的第二个十年达到峰值。20%的患者出现临床可检测到的转移，其余许多患者推测存在微转移。治疗通常包括术前化疗、手术切除和术后化疗。具有广泛手术切缘的保肢手术是手术干预的主要手段。化疗方案的进展使5年生存率达到了60%至78%。未来治疗方案的目标包括研发具有更高特异性和更低毒性的改良化疗药物。
